Abstract
A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2Rβ chain gene, were examined in both groups. No significant differences in IL- 2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2Rβ gene locus, contrary to the suggestive evidence from linkage analysis in multicase families.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 448-451 |
| Number of pages | 4 |
| Journal | American Journal of Medical Genetics - Neuropsychiatric Genetics |
| Volume | 60 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
Keywords
- IL-2 receptor
- association
- genetics
- schizophrenia
ASJC Scopus subject areas
- Genetics(clinical)
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
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