Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD

Jian Wang; Zhuo Lin Liu; Biao Chen

doi:10.1212/WNL.56.12.1757

Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD

Jian Wang, Zhuo Lin Liu, Biao Chen

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.

Original language	English (US)
Pages (from-to)	1757-1759
Number of pages	3
Journal	Neurology
Volume	56
Issue number	12
DOIs	https://doi.org/10.1212/WNL.56.12.1757
State	Published - Jun 26 2001
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1212/WNL.56.12.1757

Cite this

@article{f929eb4d50e84d5bab01b20dc28b291d,

title = "Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD",

abstract = "The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.",

author = "Jian Wang and Liu, {Zhuo Lin} and Biao Chen",

year = "2001",

month = jun,

day = "26",

doi = "10.1212/WNL.56.12.1757",

language = "English (US)",

volume = "56",

pages = "1757--1759",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "12",

}

TY - JOUR

T1 - Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD

AU - Wang, Jian

AU - Liu, Zhuo Lin

AU - Chen, Biao

PY - 2001/6/26

Y1 - 2001/6/26

N2 - The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.

AB - The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.

UR - http://www.scopus.com/inward/record.url?scp=0035954334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035954334&partnerID=8YFLogxK

U2 - 10.1212/WNL.56.12.1757

DO - 10.1212/WNL.56.12.1757

M3 - Article

C2 - 11425949

AN - SCOPUS:0035954334

SN - 0028-3878

VL - 56

SP - 1757

EP - 1759

JO - Neurology

JF - Neurology

IS - 12

ER -

Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this