@article{ec7016107e3048e0b254a602491b79b6,
title = "Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations",
abstract = "Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.",
author = "CAAPA and Michelle Daya and Nicholas Rafaels and Brunetti, {Tonya M.} and Sameer Chavan and Levin, {Albert M.} and Aniket Shetty and Gignoux, {Christopher R.} and Boorgula, {Meher Preethi} and Genevieve Wojcik and Monica Campbell and Candelaria Vergara and Torgerson, {Dara G.} and Ortega, {Victor E.} and Ayo Doumatey and Johnston, {Henry Richard} and Nathalie Acevedo and Araujo, {Maria Ilma} and Avila, {Pedro C.} and Gillian Belbin and Eugene Bleecker and Carlos Bustamante and Luis Caraballo and Alvaro Cruz and Dunston, {Georgia M.} and Celeste Eng and Faruque, {Mezbah U.} and Ferguson, {Trevor S.} and Camila Figueiredo and Ford, {Jean G.} and Weiniu Gan and Gourraud, {Pierre Antoine} and Hansel, {Nadia N.} and Hernandez, {Ryan D.} and Herrera-Paz, {Edwin Francisco} and Silvia Jim{\'e}nez and Kenny, {Eimear E.} and Jennifer Knight-Madden and Rajesh Kumar and Lange, {Leslie A.} and Lange, {Ethan M.} and Antoine Lizee and Pissamai Maul and Trevor Maul and Steven Salzberg and Beaty, {Terri H.} and Taub, {Margaret A.} and Ingo Ruczinski and Mathias, {Rasika A.} and Li Gao and Scott, {Alan F.}",
note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41467-019-08469-7",
language = "English (US)",
volume = "10",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}