Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population

Keisuke Mori, Kuniko Horie-Inoue, Masakazu Kohda, Izumi Kawasaki, Peter L. Gehlbach, Takuya Awata, Shin Yoneya, Yasushi Okazaki, Satoshi Inoue

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


The purpose of this investigation was to determine whether the high-temperature requirement A-1 (HTRA1) gene polymorphism is associated with age-related macular degeneration (AMD) in native, unrelated Japanese patients. A total of 123 patients with AMD and 133 control subjects without AMD were recruited for this study. The single-nucleotide polymorphism (SNP) rs11200638 in the HTRA1 gene was assessed using a TaqMan assay. The risk A allele frequencies in the AMD cases and control patients were 0.577 and 0.380, respectively, and were associated with a significant risk of developing AMD (p=7.75×10 -6). The results were more significant in subtype analyses with wet AMD (p=5.96×10-7). We conclude that the rs11200638 variant in the HTRA1 gene is strongly associated with AMD in the Japanese population. This result supports the hypothesis that the HTRA1 gene may increase susceptibility to AMD development and can participate in a potential new molecular pathway for AMD pathogenesis by extending this association across diverse ethnicities.

Original languageEnglish (US)
Pages (from-to)636-641
Number of pages6
JournalJournal of Human Genetics
Issue number7
StatePublished - Jun 2007


  • Age-related macular degeneration
  • High-temperature requirement A-1 (HTRA1)
  • Japanese population
  • Single-nucleotide polymorphism
  • Smoking

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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