@article{bce2aa2eacaa40f48ba05fbcc5dd9e0b,
title = "Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study",
abstract = "Objective: We examined serum lipids in association with carotid artery intima-media thickness (CIMT) in HIV-infected and HIV-uninfected women. Methods: In 2003-4, among 1827 Women's Interagency HIV Study participants, we measured CIMT and lipids (high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), non-HDL-c). A subset of 520 treated HIV-infected women had pre-1997 lipid measures. We used multivariable linear regression to examine associations between lipids and CIMT. Results: In HIV-uninfected women, higher TC, LDL-c and non-HDL-c were associated with increased CIMT. Among HIV-infected women, associations of lipids with CIMT were observed in treated but not untreated women. Among the HIV-infected women treated in 2003-4, CIMT was associated both with lipids measured a decade earlier in infection, and with late lipid measurements. Conclusion: Among HIV-infected women, hyperlipidemia is most strongly associated with subclinical atherosclerosis in treated women. Among treated women, the association appeared strongest early in the disease course.",
keywords = "Cardiovascular diseases, Carotid arteries, HAART, HIV, Lipids",
author = "Parrinello, {Christina M.} and Landay, {Alan L.} and Hodis, {Howard N.} and Gange, {Stephen J.} and Norris, {Philip J.} and Mary Young and Kathryn Anastos and Tien, {Phyllis C.} and Xiaonan Xue and Jason Lazar and Lorie Benning and Tracy, {Russell P.} and Kaplan, {Robert C.}",
note = "Funding Information: Data in this manuscript were collected by the Women's Interagency HIV Study (WIHS) Collaborative Study Group with centers (Principal Investigators) at New York City/Bronx Consortium (Kathryn Anastos); Brooklyn, NY (Howard Minkoff); Washington, DC Metropolitan Consortium (Mary Young); The Connie Wofsy Study Consortium of Northern California (Ruth Greenblatt); Los Angeles County/Southern California Consortium (Alexandra Levine); Chicago Consortium (Mardge Cohen); Data Coordinating Center (Stephen Gange). The WIHS is funded by the National Institute of Allergy and Infectious Diseases ( UO1-AI-35004 , UO1-AI-31834 , UO1-AI-34994 , UO1-AI-34989 , UO1-AI-34993 , and UO1-AI-42590 ) and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( UO1-HD-32632 ). The study is co-funded by the National Cancer Institute , the National Institute on Drug Abuse , and the National Institute on Deafness and Other Communication Disorders . Funding is also provided by the National Center for Research Resources (UCSF-CTSI Grant Number UL1 RR024131 ). Additional co-funding is provided by the National Heart, Lung and Blood Institute ( 1R01HL095140 , 1R01HL083760 to R.C.K.). Partial funding for laboratory and imaging work as well as assistance with general study coordination was provided by the University of Washington's CVD and Metabolic Complications of HIV/AIDS Data Coordinating Center ( 5R01HL095126 ). ",
year = "2012",
month = dec,
doi = "10.1016/j.atherosclerosis.2012.09.035",
language = "English (US)",
volume = "225",
pages = "408--411",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",
}