Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer

Umang Swami; Pedro Isaacsson Velho; Roberto Nussenzveig; Jonathan Chipman; Victor Sacristan Santos; Stephanie Erickson; Divya Dharmaraj; Ajjai Shivaram Alva; Ulka N. Vaishampayan; John Esther; Andrew W. Hahn; Benjamin Louis Maughan; Emmanuel S. Antonarakis; Neeraj Agarwal

doi:10.1016/j.eururo.2020.06.033

Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer

Umang Swami
, Pedro Isaacsson Velho
, Roberto Nussenzveig
, Jonathan Chipman
, Victor Sacristan Santos
, Stephanie Erickson
, Divya Dharmaraj
, Ajjai Shivaram Alva
, Ulka N. Vaishampayan
, John Esther
, Andrew W. Hahn
, Benjamin Louis Maughan
, Emmanuel S. Antonarakis
, Neeraj Agarwal

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Presence of tumor mutation in speckle-type pox virus and zinc finger protein (SPOP) gene was associated with improved survival outcomes in men with de novo metastatic castration-sensitive prostate cancer receiving standard androgen deprivation therapy.

Original language	English (US)
Pages (from-to)	652-656
Number of pages	5
Journal	European Urology
Volume	78
Issue number	5
DOIs	https://doi.org/10.1016/j.eururo.2020.06.033
State	Published - Nov 2020

Keywords

Androgen deprivation therapy
Metastatic hormone-sensitive prostate cancer
Overall survival
Progression-free survival
SPOP

ASJC Scopus subject areas

Urology

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10.1016/j.eururo.2020.06.033

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Swami, U., Isaacsson Velho, P., Nussenzveig, R., Chipman, J., Sacristan Santos, V., Erickson, S., Dharmaraj, D., Alva, A. S., Vaishampayan, U. N., Esther, J., Hahn, A. W., Maughan, B. L., Antonarakis, E. S., & Agarwal, N. (2020). Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer. European Urology, 78(5), 652-656. https://doi.org/10.1016/j.eururo.2020.06.033

Swami, U, Isaacsson Velho, P, Nussenzveig, R, Chipman, J, Sacristan Santos, V, Erickson, S, Dharmaraj, D, Alva, AS, Vaishampayan, UN, Esther, J, Hahn, AW, Maughan, BL, Antonarakis, ES & Agarwal, N 2020, 'Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer', European Urology, vol. 78, no. 5, pp. 652-656. https://doi.org/10.1016/j.eururo.2020.06.033

@article{cff3ffc005b94d2d8ccebadbe439fd6f,

title = "Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer",

abstract = "Presence of tumor mutation in speckle-type pox virus and zinc finger protein (SPOP) gene was associated with improved survival outcomes in men with de novo metastatic castration-sensitive prostate cancer receiving standard androgen deprivation therapy.",

keywords = "Androgen deprivation therapy, Metastatic hormone-sensitive prostate cancer, Overall survival, Progression-free survival, SPOP",

author = "Umang Swami and \{Isaacsson Velho\}, Pedro and Roberto Nussenzveig and Jonathan Chipman and \{Sacristan Santos\}, Victor and Stephanie Erickson and Divya Dharmaraj and Alva, \{Ajjai Shivaram\} and Vaishampayan, \{Ulka N.\} and John Esther and Hahn, \{Andrew W.\} and Maughan, \{Benjamin Louis\} and Antonarakis, \{Emmanuel S.\} and Neeraj Agarwal",

note = "Publisher Copyright: {\textcopyright} 2020 European Association of Urology",

year = "2020",

month = nov,

doi = "10.1016/j.eururo.2020.06.033",

language = "English (US)",

volume = "78",

pages = "652--656",

journal = "European Urology",

issn = "0302-2838",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer

AU - Swami, Umang

AU - Isaacsson Velho, Pedro

AU - Nussenzveig, Roberto

AU - Chipman, Jonathan

AU - Sacristan Santos, Victor

AU - Erickson, Stephanie

AU - Dharmaraj, Divya

AU - Alva, Ajjai Shivaram

AU - Vaishampayan, Ulka N.

AU - Esther, John

AU - Hahn, Andrew W.

AU - Maughan, Benjamin Louis

AU - Antonarakis, Emmanuel S.

AU - Agarwal, Neeraj

PY - 2020/11

Y1 - 2020/11

N2 - Presence of tumor mutation in speckle-type pox virus and zinc finger protein (SPOP) gene was associated with improved survival outcomes in men with de novo metastatic castration-sensitive prostate cancer receiving standard androgen deprivation therapy.

AB - Presence of tumor mutation in speckle-type pox virus and zinc finger protein (SPOP) gene was associated with improved survival outcomes in men with de novo metastatic castration-sensitive prostate cancer receiving standard androgen deprivation therapy.

KW - Androgen deprivation therapy

KW - Metastatic hormone-sensitive prostate cancer

KW - Overall survival

KW - Progression-free survival

KW - SPOP

UR - https://www.scopus.com/pages/publications/85087308453

UR - https://www.scopus.com/pages/publications/85087308453#tab=citedBy

U2 - 10.1016/j.eururo.2020.06.033

DO - 10.1016/j.eururo.2020.06.033

M3 - Article

C2 - 32624276

AN - SCOPUS:85087308453

SN - 0302-2838

VL - 78

SP - 652

EP - 656

JO - European Urology

JF - European Urology

IS - 5

ER -

Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer

Abstract

Keywords

ASJC Scopus subject areas

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