Association of major depression with sexual dysfunction in men

Louis F. Fabre, Anita H. Clayton, Louis C. Smith, Irwin M. Goldstein, Leonard R. Derogatis

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The effect of type and severity of depression on sexual functioning was examined before treatment in 591 men with Major Depression (MDD) or Atypical Depression, as determined by percentage of subjects meeting Diagnostic and Statistical Manual, 4th Edition (DSM-IV) sexual dysfunction criteria (A and B only), and percentage with Derogatis Inventory of Sexual Function (DISF) scores greater than 1 standard deviation below normal. Sexual dysfunction rates were higher for MDD than for Atypical Depression. Depression affected DISF domains differently: orgasm was most impaired, whereas sexual desire was preserved. More severe depression resulted in greater sexual dysfunction.

Original languageEnglish (US)
Pages (from-to)308-318
Number of pages11
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - 2013

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


Dive into the research topics of 'Association of major depression with sexual dysfunction in men'. Together they form a unique fingerprint.

Cite this