TY - JOUR
T1 - Association of lipids with incident heart failure among adults with and without diabetes mellitus multiethnic study of atherosclerosis
AU - Ebong, Imo A.
AU - Goff, David C.
AU - Rodriguez, Carlos J.
AU - Chen, Haiying
AU - Sibley, Christopher T.
AU - Bertoni, Alain G.
PY - 2013/5
Y1 - 2013/5
N2 - Background-Dyslipidemia is a known risk factor for coronary disease, but its role in heart failure (HF) development is less well-defined. Methods and Results-We included 5688 participants, aged 45 to 84 years, without clinical cardiovascular disease, and not receiving lipid-lowering medications at baseline, from the Multiethnic Study of Atherosclerosis. Cox-proportional hazards models were used to evaluate associations of triglyceride, total cholesterol/high-density lipoprotein-cholesterol (HDL-C) ratio, HDL-C, and non HDL-C with incident HF. We investigated for effect-modification by diabetes mellitus status and sex. During a median follow-up of 8.5 years, there were 152 incident HF cases. There were no interactions by sex. We observed significant interactions between triglyceride and diabetes mellitus (Pinteraction
AB - Background-Dyslipidemia is a known risk factor for coronary disease, but its role in heart failure (HF) development is less well-defined. Methods and Results-We included 5688 participants, aged 45 to 84 years, without clinical cardiovascular disease, and not receiving lipid-lowering medications at baseline, from the Multiethnic Study of Atherosclerosis. Cox-proportional hazards models were used to evaluate associations of triglyceride, total cholesterol/high-density lipoprotein-cholesterol (HDL-C) ratio, HDL-C, and non HDL-C with incident HF. We investigated for effect-modification by diabetes mellitus status and sex. During a median follow-up of 8.5 years, there were 152 incident HF cases. There were no interactions by sex. We observed significant interactions between triglyceride and diabetes mellitus (Pinteraction
KW - Diabetes mellitus
KW - Heart failure
KW - Lipids
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U2 - 10.1161/CIRCHEARTFAILURE.112.000093
DO - 10.1161/CIRCHEARTFAILURE.112.000093
M3 - Article
C2 - 23529112
AN - SCOPUS:84879210784
SN - 1941-3289
VL - 6
SP - 371
EP - 378
JO - Circulation: Heart Failure
JF - Circulation: Heart Failure
IS - 3
ER -