Association of Helicobacter pylori infection with dyspeptic symptoms in patients undergoing gastroduodenoscopy

Robert M. Strauss, Timothy C. Wang, Peter B. Kelsey, Carolyn C. Compton, Mary Jane Ferraro, Guillermo Perez-Perez, Julie Parsonnet, Martin J. Blaser

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


purpose: To determine the prevalence of Helicobacter pylori in patients with non-ulcer dyspepsia and ulcer disease as well as in a control population undergoing endoscopic retrograde cholangiopancreatography (ERCP) for suspected pancreatic or biliary disease. patients and methods: Forty-six eligible patients undergoing upper endoscopy at Massachusetts General Hospital were studied over a period of 18 months, as well as 24 patients undergoing ERCP for presumed pancreatic or biliary disease. Two biopsy specimens from the fundus and two from the antrum were taken for microbiologic and histopathologic analysis. Sera were examined by enzyme-linked immunoabsorbent assay. All specimens were processed in a blind fashion. Chi-square test with Yates' correction was used for statistical analysis. results: H. pylori was found in 31 of 46 (67%) study patients and in six of 24 (25%) control patients (by microbiologic or histologic techniques) (p

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalAmerican Journal of Medicine
Issue number4
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Nursing(all)


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