Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study

Lauren C. Shuffrey; Santiago Morales; Melanie H. Jacobson; Michelle Bosquet Enlow; Akhgar Ghassabian; Amy E. Margolis; Maristella Lucchini; Kecia N. Carroll; Rosa M. Crum; Dana Dabelea; Arielle Deutsch; William P. Fifer; Brandon Goldson; Christine W. Hockett; W. Alex Mason; Lisette T. Jacobson; Thomas G. O'Connor; Nicolò Pini; Yael Rayport; Ayesha Sania; Leonardo Trasande; Rosalind J. Wright; Seonjoo Lee; Catherine Monk

doi:10.1111/cdev.13938

Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study

Lauren C. Shuffrey, Santiago Morales, Melanie H. Jacobson, Michelle Bosquet Enlow, Akhgar Ghassabian, Amy E. Margolis, Maristella Lucchini, Kecia N. Carroll, Rosa M. Crum, Dana Dabelea, Arielle Deutsch, William P. Fifer, Brandon Goldson, Christine W. Hockett, W. Alex Mason, Lisette T. Jacobson, Thomas G. O'Connor, Nicolò Pini, Yael Rayport, Ayesha SaniaLeonardo Trasande, Rosalind J. Wright, Seonjoo Lee, Catherine Monk

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

This study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental influences on Child Health Outcomes (ECHO) Program from 2009-2021. GDM, prenatal, and postnatal maternal depressive symptoms were each associated with increased child externalizing and internalizing problems. GDM was associated with increased autism behaviors only among children exposed to perinatal maternal depressive symptoms above the median level. Stratified analyses revealed a relation between GDM and child outcomes in males only.

Original language	English (US)
Pages (from-to)	1595-1609
Number of pages	15
Journal	Child development
Volume	94
Issue number	6
DOIs	https://doi.org/10.1111/cdev.13938
State	Published - Nov 1 2023

ASJC Scopus subject areas

Education
Developmental and Educational Psychology
Pediatrics, Perinatology, and Child Health

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10.1111/cdev.13938

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Shuffrey, L. C., Morales, S., Jacobson, M. H., Bosquet Enlow, M., Ghassabian, A., Margolis, A. E., Lucchini, M., Carroll, K. N., Crum, R. M., Dabelea, D., Deutsch, A., Fifer, W. P., Goldson, B., Hockett, C. W., Mason, W. A., Jacobson, L. T., O'Connor, T. G., Pini, N., Rayport, Y., ... Monk, C. (2023). Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study. Child development, 94(6), 1595-1609. https://doi.org/10.1111/cdev.13938

Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study. / Shuffrey, Lauren C.; Morales, Santiago; Jacobson, Melanie H. et al.
In: Child development, Vol. 94, No. 6, 01.11.2023, p. 1595-1609.

Research output: Contribution to journal › Article › peer-review

Shuffrey, LC, Morales, S, Jacobson, MH, Bosquet Enlow, M, Ghassabian, A, Margolis, AE, Lucchini, M, Carroll, KN, Crum, RM, Dabelea, D, Deutsch, A, Fifer, WP, Goldson, B, Hockett, CW, Mason, WA, Jacobson, LT, O'Connor, TG, Pini, N, Rayport, Y, Sania, A, Trasande, L, Wright, RJ, Lee, S & Monk, C 2023, 'Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study', Child development, vol. 94, no. 6, pp. 1595-1609. https://doi.org/10.1111/cdev.13938

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title = "Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study",

abstract = "This study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental influences on Child Health Outcomes (ECHO) Program from 2009-2021. GDM, prenatal, and postnatal maternal depressive symptoms were each associated with increased child externalizing and internalizing problems. GDM was associated with increased autism behaviors only among children exposed to perinatal maternal depressive symptoms above the median level. Stratified analyses revealed a relation between GDM and child outcomes in males only.",

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AU - Jacobson, Lisette T.

AU - O'Connor, Thomas G.

AU - Pini, Nicolò

AU - Rayport, Yael

AU - Sania, Ayesha

AU - Trasande, Leonardo

AU - Wright, Rosalind J.

AU - Lee, Seonjoo

AU - Monk, Catherine

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Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems: An Environmental Influences on Child Health Outcomes (ECHO) Study

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