Association of genetic ancestry with preterm delivery and related traits among African American mothers

Hui Ju Tsai; Yunxian Yu; Shanchun Zhang; Colleen Pearson; Katherin Ortiz; Xiping Xu; Howard Bauchner; Barry Zuckerman; Xiaobin Wang

doi:10.1016/j.ajog.2009.02.027

Association of genetic ancestry with preterm delivery and related traits among African American mothers

Hui Ju Tsai, Yunxian Yu, Shanchun Zhang, Colleen Pearson, Katherin Ortiz, Xiping Xu, Howard Bauchner, Barry Zuckerman, Xiaobin Wang

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective: In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors. Study Design: We genotyped 812 mothers in a case-control PTD study at Boston Medical Center who self-reported their ethnicity as "black." Regression analysis and Wilcoxon rank-sum test were applied to evaluate ancestral distribution and the association between genetic ancestry and PTD-related traits, as well as the potential confounding effect of population stratification. Results: The estimated African ancestral proportion was 0.90 ± 0.13. We found significant associations of ancestral proportion with PTD as a whole and PTD subgrouped by the presence of maternal hypertensive disorders. We did not observe significant confounding as a result of population stratification in this case-control PTD study. Conclusion: Our data underline the need for more intensive investigation of genetic admixture in African Americans to identify novel susceptibility genes of PTD.

Original language	English (US)
Pages (from-to)	94.e1-94.e10
Journal	American journal of obstetrics and gynecology
Volume	201
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2009.02.027
State	Published - Jul 2009
Externally published	Yes

Keywords

admixture
genetic ancestry
population stratification

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2009.02.027

Cite this

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title = "Association of genetic ancestry with preterm delivery and related traits among African American mothers",

abstract = "Objective: In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors. Study Design: We genotyped 812 mothers in a case-control PTD study at Boston Medical Center who self-reported their ethnicity as {"}black.{"} Regression analysis and Wilcoxon rank-sum test were applied to evaluate ancestral distribution and the association between genetic ancestry and PTD-related traits, as well as the potential confounding effect of population stratification. Results: The estimated African ancestral proportion was 0.90 ± 0.13. We found significant associations of ancestral proportion with PTD as a whole and PTD subgrouped by the presence of maternal hypertensive disorders. We did not observe significant confounding as a result of population stratification in this case-control PTD study. Conclusion: Our data underline the need for more intensive investigation of genetic admixture in African Americans to identify novel susceptibility genes of PTD.",

keywords = "admixture, genetic ancestry, population stratification",

author = "Tsai, {Hui Ju} and Yunxian Yu and Shanchun Zhang and Colleen Pearson and Katherin Ortiz and Xiping Xu and Howard Bauchner and Barry Zuckerman and Xiaobin Wang",

note = "Funding Information: The study was supported in part by Grants from the National Institute of Child Health and Human Development (R01 HD41702; K24 HD 042489), National Institute of Environmental Health Sciences (R01ES11682, R21ES11666), March of Dimes Birth Defects Foundation (20-FY98-0701, 20-FY02-56 and #21-FY07-605), and Food Allergy Project. ",

year = "2009",

month = jul,

doi = "10.1016/j.ajog.2009.02.027",

language = "English (US)",

volume = "201",

pages = "94.e1--94.e10",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

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TY - JOUR

T1 - Association of genetic ancestry with preterm delivery and related traits among African American mothers

AU - Tsai, Hui Ju

AU - Yu, Yunxian

AU - Zhang, Shanchun

AU - Pearson, Colleen

AU - Ortiz, Katherin

AU - Xu, Xiping

AU - Bauchner, Howard

AU - Zuckerman, Barry

AU - Wang, Xiaobin

N1 - Funding Information: The study was supported in part by Grants from the National Institute of Child Health and Human Development (R01 HD41702; K24 HD 042489), National Institute of Environmental Health Sciences (R01ES11682, R21ES11666), March of Dimes Birth Defects Foundation (20-FY98-0701, 20-FY02-56 and #21-FY07-605), and Food Allergy Project.

PY - 2009/7

Y1 - 2009/7

N2 - Objective: In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors. Study Design: We genotyped 812 mothers in a case-control PTD study at Boston Medical Center who self-reported their ethnicity as "black." Regression analysis and Wilcoxon rank-sum test were applied to evaluate ancestral distribution and the association between genetic ancestry and PTD-related traits, as well as the potential confounding effect of population stratification. Results: The estimated African ancestral proportion was 0.90 ± 0.13. We found significant associations of ancestral proportion with PTD as a whole and PTD subgrouped by the presence of maternal hypertensive disorders. We did not observe significant confounding as a result of population stratification in this case-control PTD study. Conclusion: Our data underline the need for more intensive investigation of genetic admixture in African Americans to identify novel susceptibility genes of PTD.

AB - Objective: In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors. Study Design: We genotyped 812 mothers in a case-control PTD study at Boston Medical Center who self-reported their ethnicity as "black." Regression analysis and Wilcoxon rank-sum test were applied to evaluate ancestral distribution and the association between genetic ancestry and PTD-related traits, as well as the potential confounding effect of population stratification. Results: The estimated African ancestral proportion was 0.90 ± 0.13. We found significant associations of ancestral proportion with PTD as a whole and PTD subgrouped by the presence of maternal hypertensive disorders. We did not observe significant confounding as a result of population stratification in this case-control PTD study. Conclusion: Our data underline the need for more intensive investigation of genetic admixture in African Americans to identify novel susceptibility genes of PTD.

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KW - genetic ancestry

KW - population stratification

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Association of genetic ancestry with preterm delivery and related traits among African American mothers

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