TY - JOUR
T1 - Association of Gag-specific T lymphocyte responses during the early phase of human immunodeficiency virus type 1 infection and lower virus load set point
AU - Patke, Deepa S.
AU - Langan, Susan J.
AU - Carruth, Lucy Minnich
AU - Keating, Sheila M.
AU - Sabundayo, Beulah P.
AU - Margolick, Joseph B.
AU - Quinn, Thomas C.
AU - Bollinger, Robert C.
N1 - Funding Information:
Financial support: National Institute of Allergy and Infectious Diseases (grant AI41532); National Institutes of Health (NIH); NIH–Fogarty International Center, Program of International Training Grants in Epidemiology Related to AIDS (grant D43-TW0000).
PY - 2002/10/15
Y1 - 2002/10/15
N2 - T lymphocyte responses to human immunodeficiency virus (HIV) type 1 Gag were measured in 9 patients by interferon-γ enzyme-linked immunospot assay at 3 time points within 12 months of infection. Patients with early recognition of HIV-1 Gag had lower subsequent HIV-1 load set points, as measured during the first 2 years of infection, compared with those of patients with undetectable Gag-specific responses (median, 4.27 vs. 5.05 log10 HIV-1 RNA copies/mL, respectively; P = .028). An inverse correlation existed between the magnitude of the Gag-specific responses and the HIV-1 load set point (r = -0.733; P = .025). Early sustained T lymphocyte responses to HIV-1 Gag may be important for the establishment of virus load set point.
AB - T lymphocyte responses to human immunodeficiency virus (HIV) type 1 Gag were measured in 9 patients by interferon-γ enzyme-linked immunospot assay at 3 time points within 12 months of infection. Patients with early recognition of HIV-1 Gag had lower subsequent HIV-1 load set points, as measured during the first 2 years of infection, compared with those of patients with undetectable Gag-specific responses (median, 4.27 vs. 5.05 log10 HIV-1 RNA copies/mL, respectively; P = .028). An inverse correlation existed between the magnitude of the Gag-specific responses and the HIV-1 load set point (r = -0.733; P = .025). Early sustained T lymphocyte responses to HIV-1 Gag may be important for the establishment of virus load set point.
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U2 - 10.1086/343811
DO - 10.1086/343811
M3 - Article
C2 - 12355372
AN - SCOPUS:0037108823
SN - 0022-1899
VL - 186
SP - 1177
EP - 1180
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 8
ER -