TY - JOUR
T1 - Association of adiposity trajectories with insulin sensitivity and glycemic deterioration
T2 - A longitudinal study of rural Chinese twin adults
AU - Liu, Rong
AU - Brickman, Wendy J.
AU - Christoffel, Katherine K.
AU - Liu, Xin
AU - Wang, Guoying
AU - Arguelles, Lester
AU - Zhang, Shanchun
AU - Zimmerman, Donald
AU - Wang, Binyan
AU - Xu, Xiping
AU - Li, Zhiping
AU - Xing, Houxun
AU - Wang, Xiaobin
N1 - Funding Information:
Manuscript received March 21, 2006; revised May 30, 2006. This work was supported in part by Central Queensland University for the Research Advancement Awards Scheme Project “Robust Fault Detection, Filtering and Control for Uncertain Systems With Time-Varying Delay” (January 2006–December 2008). This paper was recommended by Associate Editor Y. Lian.
PY - 2012/7
Y1 - 2012/7
N2 - OBJECTIVE - To evaluate associations between adiposity trajectories over time and insulin sensitivity and glucose deterioration in a Chinese twin cohort. RESEARCH DESIGN AND METHODS - This study focused on 341 males and 292 females aged 20-50 years at baseline who had physical clinical examinations and oral glucose tolerance test at two time points with an average of 6 years apart. BMI, waist circumference, percent body fat (PBF), and percent trunk fat (PTF) trajectories were classified into five track groups based on age- and sex-specific tertiles at each visit. We calculated the odds of the insulin sensitivity index (0,120)[ISI (0,120)] or glycemic deterioration at follow-up among five defined trajectories (tertile baseline → tertile follow-up) using generalized estimate equationmodels. Additionally, we applied structural equation models to examine genetic and environmental influences on adiposity, adiposity change over time (ACO), ISI (0,120), and the interrelationships among them. RESULTS - Participants with stable adiposity (BMI, waist circumference, PBF, and PTF) in the highest tertile or shifting to the highest tertile tended to have the lowest ISI (0,120) at follow-up or experience glycemic deterioration. Genetic factors exerted the major influence on adiposity, but environmental factors unique to each twin contributed more strongly to ISI and ACO. Correlations between adiposity/ACO and insulin sensitivity were mainly due to environmental influences. CONCLUSIONS - When adiposity stays or becomes high, insulin sensitivity falls and risk of glycemic deterioration rises. Additionally, we found that genetic factors exerted the major influence on adiposity, while environmental factors played the principal role for ACO and insulin sensitivity.
AB - OBJECTIVE - To evaluate associations between adiposity trajectories over time and insulin sensitivity and glucose deterioration in a Chinese twin cohort. RESEARCH DESIGN AND METHODS - This study focused on 341 males and 292 females aged 20-50 years at baseline who had physical clinical examinations and oral glucose tolerance test at two time points with an average of 6 years apart. BMI, waist circumference, percent body fat (PBF), and percent trunk fat (PTF) trajectories were classified into five track groups based on age- and sex-specific tertiles at each visit. We calculated the odds of the insulin sensitivity index (0,120)[ISI (0,120)] or glycemic deterioration at follow-up among five defined trajectories (tertile baseline → tertile follow-up) using generalized estimate equationmodels. Additionally, we applied structural equation models to examine genetic and environmental influences on adiposity, adiposity change over time (ACO), ISI (0,120), and the interrelationships among them. RESULTS - Participants with stable adiposity (BMI, waist circumference, PBF, and PTF) in the highest tertile or shifting to the highest tertile tended to have the lowest ISI (0,120) at follow-up or experience glycemic deterioration. Genetic factors exerted the major influence on adiposity, but environmental factors unique to each twin contributed more strongly to ISI and ACO. Correlations between adiposity/ACO and insulin sensitivity were mainly due to environmental influences. CONCLUSIONS - When adiposity stays or becomes high, insulin sensitivity falls and risk of glycemic deterioration rises. Additionally, we found that genetic factors exerted the major influence on adiposity, while environmental factors played the principal role for ACO and insulin sensitivity.
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U2 - 10.2337/dc11-2060
DO - 10.2337/dc11-2060
M3 - Article
C2 - 22596174
AN - SCOPUS:84862891223
SN - 1935-5548
VL - 35
SP - 1506
EP - 1512
JO - Diabetes Care
JF - Diabetes Care
IS - 7
ER -