TY - JOUR
T1 - Association between the blood pressure response to a change in posture and the 6-year incidence of hypertension
T2 - Prospective findings from the ARIC study
AU - Rose, Kathryn M.
AU - Holme, I.
AU - Light, K. C.
AU - Sharrett, A. R.
AU - Tyroler, H. A.
AU - Heiss, G.
N1 - Funding Information:
This work was supported by NHLBI Contracts N01-HC-55015, N01-HC-55016, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022 and by National Institutes of Health, NHLBI NRSA grant 5T32HL07055. The authors thank the staff and participants in the ARIC Study for their important contributions.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - The association between the blood pressure response to a change from the supine to the standing position and the 6-year incidence of hypertension was studied in a biethnic, middle-aged cohort of 6951 normotensive men and women free of coronary heart disease at baseline. Postural change in systolic blood pressure (SBP) was categorized into deciles, and the middle four deciles served as the referent (no change) group. In unadjusted analyses, the incidence of hypertension was higher among both those with SBP increases and decreases relative to those in the referent group. Associations were modestly attenuated after controlling for age, ethnicity, and gender and cardiovascular disease risk factors. However, after adjustment for baseline, seated SBP, a modest association with incident hypertension persisted only for SBP decreases. orthostatic hypotension (upon standing) was associated with incident hypertension and isolated systolic hypertension and, unexpectedly, this increased risk was highest among those with the lowest levels of baseline, resting SBP.
AB - The association between the blood pressure response to a change from the supine to the standing position and the 6-year incidence of hypertension was studied in a biethnic, middle-aged cohort of 6951 normotensive men and women free of coronary heart disease at baseline. Postural change in systolic blood pressure (SBP) was categorized into deciles, and the middle four deciles served as the referent (no change) group. In unadjusted analyses, the incidence of hypertension was higher among both those with SBP increases and decreases relative to those in the referent group. Associations were modestly attenuated after controlling for age, ethnicity, and gender and cardiovascular disease risk factors. However, after adjustment for baseline, seated SBP, a modest association with incident hypertension persisted only for SBP decreases. orthostatic hypotension (upon standing) was associated with incident hypertension and isolated systolic hypertension and, unexpectedly, this increased risk was highest among those with the lowest levels of baseline, resting SBP.
KW - Isolated systolic hypertension
KW - Orthostatic hypotension
KW - Postural blood pressure change
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U2 - 10.1038/sj.jhh.1001482
DO - 10.1038/sj.jhh.1001482
M3 - Article
C2 - 12444538
AN - SCOPUS:0036865938
SN - 0950-9240
VL - 16
SP - 771
EP - 777
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
IS - 11
ER -