@article{53e3ff5a574a4db294504d624a04f79c,
title = "Association between prenatal dietary methyl mercury exposure and developmental outcomes on acquisition of articulatory-phonologic skills in children in the Republic of Seychelles",
abstract = "Methyl mercury (MeHg) is a neurotoxicant that with sufficient exposure can seriously impair the central nervous system and cause mental retardation, cerebral palsy, and neuromotor dysfunction. The level of exposure needed to adversely affect the nervous system is unknown. Human exposure to low levels of MeHg is common from consumption of fish. We examined the relationship between MeHg exposure and development of articulatory-phonologic speech skills in children whose mothers consumed a diet high in fish during pregnancy to determine whether any adverse associations could be detected. A total of 544 children from the Republic of Seychelles were given a speech assessment when they were 66 months of age. Exposure level was determined by measuring MeHg in maternal hair growing during pregnancy. No adverse associations between articulatory- phonologic speech skills and prenatal MeHg exposure were detected. The findings of this investigation are compatible with previous developmental assessments of Seychellois children that have indicated no adverse effects of prenatal MeHg exposure from fish consumption.",
keywords = "Seychelles child development study, methyl mercury, ocean fish consumption, phonologic development, prenatal exposure, speech articulation",
author = "Young, {Edna Carter} and Davidson, {Philip W.} and Gregory Wilding and Myers, {Gary J.} and Conrad Shamlaye and Christopher Cox and {de Broeck}, Jan and Bennett, {Carolyn M.} and Reeves, {Jean Sloane}",
note = "Funding Information: NIH, USA, and its contents are solely the responsibility of the authors and do not necessarily represent the official view of the NIEHS, NIH. This research was also supported by a grant from the Food and Drug Administration, US Department of Health and Human Services, and by the Ministry of Health, Republic of Seychelles. Funding Information: Acknowledgements The research protocols were reviewed and approved by the Institutional Review Boards of both the University of Rochester and the Republic of Seychelles. The authors wish to acknowledge the University of Rochester Environmental Health Sciences Center Analytical Core (Thomas Clarkson and Elsa Cernichiari) for conducting the mercury analyses. We are grateful also to Professor Clarkson for critical reading of the manuscript. The project described was supported by Seychelles Child Development Study (Grant numbers R01 ES008442 and T32-ES007271) from the National Institute of Enviromental Health Sciences (NIEHS), Publisher Copyright: {\textcopyright} 2021",
year = "2020",
month = dec,
doi = "10.1016/j.neuro.2020.09.028",
language = "English (US)",
volume = "81",
pages = "353--357",
journal = "NeuroToxicology",
issn = "0161-813X",
publisher = "Elsevier",
}