TY - JOUR
T1 - Association between O blood group and occurrence and severity of diarrhoea due to Escherichia coli
AU - Black, Robert E.
AU - Levine, Myron M.
AU - Clements, Mary Lou
AU - Hughes, Timothy
AU - O'Donnell, Sylvia
N1 - Funding Information:
Acknowledgements These studies were supported by research contracts NOlAI42553 and NOlAI13666 from the National Institute of Allergy and InfectiousD iseasesa nd DAMD17-78-C-80-11f rom the U.S. Army Medical Researcha nd Development Commanda nd by a grantf rom the World Health Orgar&a-tion.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - During studies of diarrhoea due to Escherichia coli in 316 adult volunteers, ABO and Rh blood group determinations were done to look for differences in the occurrence or severity of illness in association with certain blood groups. In studies using heat-labile enterotoxin-producing E. coli, volunteers with O blood group had a significantly higher attack rate for diarrhoea than persons with other blood groups. In contrast, in studies with enteropathogenic or heat-stable enterotoxin-producing E. coli, no association was found between occurrence of diarrhoea and ABO group. These studies, and previous studies finding a similarly increased susceptibility to cholera in persons with O blood group, suggest that the mechanism of increased risk involves an interaction between blood group substances and the similar enterotoxin produced by E. coli and Vibrio cholerae.
AB - During studies of diarrhoea due to Escherichia coli in 316 adult volunteers, ABO and Rh blood group determinations were done to look for differences in the occurrence or severity of illness in association with certain blood groups. In studies using heat-labile enterotoxin-producing E. coli, volunteers with O blood group had a significantly higher attack rate for diarrhoea than persons with other blood groups. In contrast, in studies with enteropathogenic or heat-stable enterotoxin-producing E. coli, no association was found between occurrence of diarrhoea and ABO group. These studies, and previous studies finding a similarly increased susceptibility to cholera in persons with O blood group, suggest that the mechanism of increased risk involves an interaction between blood group substances and the similar enterotoxin produced by E. coli and Vibrio cholerae.
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U2 - 10.1016/0035-9203(87)90302-6
DO - 10.1016/0035-9203(87)90302-6
M3 - Article
C2 - 3127953
AN - SCOPUS:0023511660
SN - 0035-9203
VL - 81
SP - 120
EP - 123
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 1
ER -