TY - JOUR
T1 - Association between Left Atrial Late Gadolinium Enhancement and Atrial Fibrillation
T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)
AU - Zghaib, Tarek
AU - Silva, Thiago Quinaglia A.C.
AU - Ambale-Venkatesh, Bharath
AU - Xie, Eric
AU - Ostovaneh, Mohammad R.
AU - Habibi, Mohammadali
AU - Bluemke, David A.
AU - Soliman, Elsayed Z.
AU - Wu, Colin O.
AU - Heckbert, Susan R.
AU - Nazarian, Saman
AU - Lima, João A.C.
N1 - Publisher Copyright:
© RSNA, 2023.
PY - 2023
Y1 - 2023
N2 - Purpose: To determine the prevalence and correlates of left atrial (LA) late gadolinium enhancement (LGE) at cardiac MRI and its association with atrial fibrillation (AF) in a population-based sample from the Multi-Ethnic Study of Atherosclerosis (MESA). Materials and Methods: In this secondary post hoc analysis of the MESA cohort (ClinicalTrials.gov no. NCT00005487), participants without AF underwent LGE cardiac MRI at the fifth examination (2010–2012). LA LGE burden was quantified using the image intensity ratio technique on biplane long-axis two-dimensional (2D) LGE images without fat saturation. Survival analysis was performed with log-rank testing and Cox regression. Results: Of 1697 participants (mean age, 67 years ± 9 [SD]; 872 men), 1035 (61%) had LA LGE, and 75 (4.4%) developed AF during follow-up (median, 3.95 years). At univariable analysis, LA LGE was associated with age (β =.010 [95% CI:.005,.015], P <.001), diastolic blood pressure (β =.005 [95% CI:.001,.009], P =.02), HbA1c level (β =.06 [95% CI:.02,.11], P =.009), heart fail-ure (β =.60 [95% CI:.11, 1.08], P =.02), LA volume (β =.008 [95% CI:.004,.012], P <.001), and LA function (emptying fraction, LA global longitudinal strain, LA early diastolic peak longitudinal strain rate, and LA late diastolic peak strain rate; all P <.05). After adjusting for the variables in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) AF score, LA LGE independently helped predict incident AF (hazard ratio = 1.46 [95% CI: 1.13, 1.88], P =.003). The highest tertile (LGE > 2%) was twice as likely to develop AF. Conclusion: Although limited by the 2D LGE technique employed, LA LGE was associated with adverse atrial remodeling and helped predict AF in a multiethnic population–based sample.
AB - Purpose: To determine the prevalence and correlates of left atrial (LA) late gadolinium enhancement (LGE) at cardiac MRI and its association with atrial fibrillation (AF) in a population-based sample from the Multi-Ethnic Study of Atherosclerosis (MESA). Materials and Methods: In this secondary post hoc analysis of the MESA cohort (ClinicalTrials.gov no. NCT00005487), participants without AF underwent LGE cardiac MRI at the fifth examination (2010–2012). LA LGE burden was quantified using the image intensity ratio technique on biplane long-axis two-dimensional (2D) LGE images without fat saturation. Survival analysis was performed with log-rank testing and Cox regression. Results: Of 1697 participants (mean age, 67 years ± 9 [SD]; 872 men), 1035 (61%) had LA LGE, and 75 (4.4%) developed AF during follow-up (median, 3.95 years). At univariable analysis, LA LGE was associated with age (β =.010 [95% CI:.005,.015], P <.001), diastolic blood pressure (β =.005 [95% CI:.001,.009], P =.02), HbA1c level (β =.06 [95% CI:.02,.11], P =.009), heart fail-ure (β =.60 [95% CI:.11, 1.08], P =.02), LA volume (β =.008 [95% CI:.004,.012], P <.001), and LA function (emptying fraction, LA global longitudinal strain, LA early diastolic peak longitudinal strain rate, and LA late diastolic peak strain rate; all P <.05). After adjusting for the variables in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) AF score, LA LGE independently helped predict incident AF (hazard ratio = 1.46 [95% CI: 1.13, 1.88], P =.003). The highest tertile (LGE > 2%) was twice as likely to develop AF. Conclusion: Although limited by the 2D LGE technique employed, LA LGE was associated with adverse atrial remodeling and helped predict AF in a multiethnic population–based sample.
KW - Cardiac
KW - Epidemiology
KW - MR Imaging
UR - http://www.scopus.com/inward/record.url?scp=85171433649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85171433649&partnerID=8YFLogxK
U2 - 10.1148/ryct.220047
DO - 10.1148/ryct.220047
M3 - Article
C2 - 37693199
AN - SCOPUS:85171433649
SN - 2638-6135
VL - 5
JO - Radiology: Cardiothoracic Imaging
JF - Radiology: Cardiothoracic Imaging
IS - 4
M1 - e220047
ER -