TY - JOUR
T1 - Association between high-density lipoprotein subfractions and low-grade inflammation, insulin resistance, and metabolic syndrome components
T2 - The ELSA-Brasil study
AU - Generoso, Giuliano
AU - Bensenor, Isabela M.
AU - Santos, Raul D.
AU - Santos, Itamar S.
AU - Goulart, Alessandra C.
AU - Jones, Steven R.
AU - Kulkarni, Krishnaji R.
AU - Blaha, Michael J.
AU - Toth, Peter P.
AU - Lotufo, Paulo A.
AU - Bittencourt, Marcio Sommer
N1 - Publisher Copyright:
© 2018 National Lipid Association
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Background: High-density lipoprotein cholesterol (HDL-C) can be divided into subfractions, which may have variable effects in atherogenesis. The results about the association between HDL-C subfractions and risk factors for cardiovascular disease are mixed. Objective: The objective of this study was to analyze the association between HDL-C subfractions and each metabolic syndrome component, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and C-reactive protein (CRP). Methods: Four thousand five hundred thirty-two individuals between 35 and 74 years old without previous manifest cardiovascular disease not using fibrates were enrolled. HDL-C subfractions were separated by vertical ultracentrifugation (vertical auto profile—in mg/dL) into HDL2-C and HDL3-C. HDL2-C/HDL3-C ratio, HOMA-IR, and high-sensitivity CRP were also included in the analysis. Results: Mean age of participants was 51 ± 9 years, and 54.8% were women. In univariate analysis, HDL-C, HDL2-C, and HDL3-C were all inversely associated with each of the metabolic syndrome defining factors, HOMA-IR values, and serum CRP. We also observed a negative association between HDL2-C/HDL3-C ratio with the variables aforementioned even after adjusting for smoking, alcohol use, physical activity, and HDL-C levels (P <.01). Conclusion: HDL-C and its subfractions (HDL2-C and HDL3-C) are inversely associated with the defining features of metabolic syndrome, insulin resistance, and systemic inflammation. In addition, the HDL2-C/HDL3-C ratio measured by vertical auto profile is significantly associated with the former factors even after comprehensive adjustment for HDL-C and other confounding variables.
AB - Background: High-density lipoprotein cholesterol (HDL-C) can be divided into subfractions, which may have variable effects in atherogenesis. The results about the association between HDL-C subfractions and risk factors for cardiovascular disease are mixed. Objective: The objective of this study was to analyze the association between HDL-C subfractions and each metabolic syndrome component, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and C-reactive protein (CRP). Methods: Four thousand five hundred thirty-two individuals between 35 and 74 years old without previous manifest cardiovascular disease not using fibrates were enrolled. HDL-C subfractions were separated by vertical ultracentrifugation (vertical auto profile—in mg/dL) into HDL2-C and HDL3-C. HDL2-C/HDL3-C ratio, HOMA-IR, and high-sensitivity CRP were also included in the analysis. Results: Mean age of participants was 51 ± 9 years, and 54.8% were women. In univariate analysis, HDL-C, HDL2-C, and HDL3-C were all inversely associated with each of the metabolic syndrome defining factors, HOMA-IR values, and serum CRP. We also observed a negative association between HDL2-C/HDL3-C ratio with the variables aforementioned even after adjusting for smoking, alcohol use, physical activity, and HDL-C levels (P <.01). Conclusion: HDL-C and its subfractions (HDL2-C and HDL3-C) are inversely associated with the defining features of metabolic syndrome, insulin resistance, and systemic inflammation. In addition, the HDL2-C/HDL3-C ratio measured by vertical auto profile is significantly associated with the former factors even after comprehensive adjustment for HDL-C and other confounding variables.
KW - High-density lipoprotein subfractions
KW - Insulin resistance
KW - Low-grade inflammation
KW - Metabolic syndrome
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U2 - 10.1016/j.jacl.2018.05.003
DO - 10.1016/j.jacl.2018.05.003
M3 - Article
C2 - 29941395
AN - SCOPUS:85048886031
SN - 1933-2874
VL - 12
SP - 1290-1297.e1
JO - Journal of clinical lipidology
JF - Journal of clinical lipidology
IS - 5
ER -