TY - JOUR
T1 - Association Between Dietary Patterns and Kidney Function in Patients With Chronic Kidney Disease
T2 - A Cross-Sectional Analysis of the German Chronic Kidney Disease Study
AU - GCKD Study Investigators
AU - Heindel, Judith
AU - Baid-Agrawal, Seema
AU - Rebholz, Casey M.
AU - Nadal, Jennifer
AU - Schmid, Matthias
AU - Schaeffner, Elke
AU - Schneider, Markus P.
AU - Meiselbach, Heike
AU - Kaesler, Nadine
AU - Bergmann, Manuela
AU - Ernst, Sabine
AU - Krane, Vera
AU - Eckardt, Kai Uwe
AU - Floege, Jürgen
AU - Schlieper, Georg
AU - Saritas, Turgay
N1 - Funding Information:
Support: The GCKD study is supported by the German Ministry of Education and Research grant number 01ER 0804, 01ER 0818, 01ER 0819, 01ER 0820, and 01ER 0821, the KfH Foundation for Preventive Medicine and corporate sponsors (www.gckd.org). The funders of this study did not have any role in study design; collection, analysis, and interpretation of data; writing the report; and the decision to submit the report for publication. C.M.R. is supported by a mentored research scientist development award from the National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK107782) and a grant from the National Heart, Lung, and Blood Institute (R21 HL143089).
Publisher Copyright:
© 2019 National Kidney Foundation, Inc.
PY - 2020/7
Y1 - 2020/7
N2 - Objective: In the general population, “healthy” dietary patterns are associated with improved health outcomes, but data on associations between observance of specific dietary patterns and kidney function in patients with chronic kidney disease (CKD) are sparse. Methods: Dietary intake was evaluated using food frequency questionnaires in patients with moderately severe CKD under nephrology care enrolled into the observational multicenter German CKD study. The Dietary Approaches to Stop Hypertension (DASH) diet score, Mediterranean diet score, and German Food Pyramid Index (GFPI) were calculated and their association with estimated glomerular filtration rate (eGFR) and albuminuria was assessed by multivariable linear regression analysis, adjusted for gender, age, body mass index, energy intake, smoking status, alcohol intake, education, high-density lipoprotein-cholesterol (HDL- cholesterol), low-density lipoprotein-cholesterol (LDL-cholesterol), hypertension, and diabetes mellitus. Results: A total of 2,813 patients (41% women; age 60.1 ± 11.6 years) were included in the analysis. High DASH diet score and GFPI were associated with lower systolic blood pressure and lower intake of antihypertensive medication, higher HDL, and lower uric acid levels. Mediterranean-style diet was associated with lower prevalence of diabetes mellitus. Higher DASH and Mediterranean diet scores were associated with higher eGFR (β-coefficient = 1.226, P <.001; β-coefficient = 0.932, P =.007, respectively). In contrast, GFPI was not associated with eGFR. For the individual components of the dietary patterns, higher intake of nuts and legumes, cereals, fish, and polyunsaturated fats was associated with higher eGFR and higher intake of dairy, composed of low- and whole-fat dairy, was associated with lower eGFR. No association was found between dietary patterns and albuminuria. Conclusion: Higher observance of the DASH or Mediterranean diet, but not German food pyramid recommendations, was associated with higher eGFR among patients with CKD. Improving dietary habits may offer an opportunity to better control comorbidities and kidney function decline in patients with CKD.
AB - Objective: In the general population, “healthy” dietary patterns are associated with improved health outcomes, but data on associations between observance of specific dietary patterns and kidney function in patients with chronic kidney disease (CKD) are sparse. Methods: Dietary intake was evaluated using food frequency questionnaires in patients with moderately severe CKD under nephrology care enrolled into the observational multicenter German CKD study. The Dietary Approaches to Stop Hypertension (DASH) diet score, Mediterranean diet score, and German Food Pyramid Index (GFPI) were calculated and their association with estimated glomerular filtration rate (eGFR) and albuminuria was assessed by multivariable linear regression analysis, adjusted for gender, age, body mass index, energy intake, smoking status, alcohol intake, education, high-density lipoprotein-cholesterol (HDL- cholesterol), low-density lipoprotein-cholesterol (LDL-cholesterol), hypertension, and diabetes mellitus. Results: A total of 2,813 patients (41% women; age 60.1 ± 11.6 years) were included in the analysis. High DASH diet score and GFPI were associated with lower systolic blood pressure and lower intake of antihypertensive medication, higher HDL, and lower uric acid levels. Mediterranean-style diet was associated with lower prevalence of diabetes mellitus. Higher DASH and Mediterranean diet scores were associated with higher eGFR (β-coefficient = 1.226, P <.001; β-coefficient = 0.932, P =.007, respectively). In contrast, GFPI was not associated with eGFR. For the individual components of the dietary patterns, higher intake of nuts and legumes, cereals, fish, and polyunsaturated fats was associated with higher eGFR and higher intake of dairy, composed of low- and whole-fat dairy, was associated with lower eGFR. No association was found between dietary patterns and albuminuria. Conclusion: Higher observance of the DASH or Mediterranean diet, but not German food pyramid recommendations, was associated with higher eGFR among patients with CKD. Improving dietary habits may offer an opportunity to better control comorbidities and kidney function decline in patients with CKD.
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U2 - 10.1053/j.jrn.2019.09.008
DO - 10.1053/j.jrn.2019.09.008
M3 - Article
C2 - 31761711
AN - SCOPUS:85076548690
SN - 1051-2276
VL - 30
SP - 296
EP - 304
JO - Journal of Renal Nutrition
JF - Journal of Renal Nutrition
IS - 4
ER -