TY - JOUR
T1 - Association between circulating Galectin-3 and arterial stiffness in older adults
T2 - Atherosclerosis Risk in Communities (ARIC) Study
AU - Jia, Xiaoming
AU - Sun, Caroline
AU - Tanaka, Hirofumi
AU - Al Rifai, Mahmoud
AU - Aguilar, David
AU - Ndumele, Chiadi
AU - Selvin, Elizabeth
AU - Virani, Salim S.
AU - Hoogeveen, Ron C.
AU - Heiss, Gerardo
AU - Ballantyne, Christie M.
AU - Nambi, Vijay
N1 - Publisher Copyright:
© 2021 Hogrefe Verlag GmbH & Co. KG. All rights reserved.
PY - 2021/11
Y1 - 2021/11
N2 - Background: Galectin-3 (gal-3) is a β-galactoside-binding lectin associated tissue fibrosis and inflammation. There is limited understanding of the relationship between gal-3 and vascular health. Our aim was to assess the association between gal-3 and arterial stiffness in older adults. Methods: We conducted a cross-sectional study of 4275 participants (mean age of 75 years) from the Atherosclerosis Risk in Communities (ARIC) Study. Central arterial stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). We evaluated the association of gal-3 with cfPWV using multivariable linear regression. Results: The median (interquartile range) gal-3 concentration was 16.5 (13.8, 19.8) ng/mL and mean cfPWV was 1163303 cm/s. Higher gal-3 concentration was associated with greater central arterial stiffness after adjustment for age, sex, race-center, heart rate, systolic blood pressure, anti-hypertensive medication use, and current smoking status (β=36.4 cm/s change in cfPWV per log unit change in gal-3; 95% CI: 7.2, 65.5, p=0.015). The association was attenuated after adjusting for additional cardiovascular risk factors (β=17.3, 95% CI: -14.4, 49.0). Conclusions: In community-dwelling older adults, gal-3 concentration was associated with central arterial stiffness, likely sharing common pathways with traditional cardiovascular risk factors.
AB - Background: Galectin-3 (gal-3) is a β-galactoside-binding lectin associated tissue fibrosis and inflammation. There is limited understanding of the relationship between gal-3 and vascular health. Our aim was to assess the association between gal-3 and arterial stiffness in older adults. Methods: We conducted a cross-sectional study of 4275 participants (mean age of 75 years) from the Atherosclerosis Risk in Communities (ARIC) Study. Central arterial stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). We evaluated the association of gal-3 with cfPWV using multivariable linear regression. Results: The median (interquartile range) gal-3 concentration was 16.5 (13.8, 19.8) ng/mL and mean cfPWV was 1163303 cm/s. Higher gal-3 concentration was associated with greater central arterial stiffness after adjustment for age, sex, race-center, heart rate, systolic blood pressure, anti-hypertensive medication use, and current smoking status (β=36.4 cm/s change in cfPWV per log unit change in gal-3; 95% CI: 7.2, 65.5, p=0.015). The association was attenuated after adjusting for additional cardiovascular risk factors (β=17.3, 95% CI: -14.4, 49.0). Conclusions: In community-dwelling older adults, gal-3 concentration was associated with central arterial stiffness, likely sharing common pathways with traditional cardiovascular risk factors.
KW - Galectin-3
KW - aging
KW - arterial stiffness
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U2 - 10.1024/0301-1526/a000968
DO - 10.1024/0301-1526/a000968
M3 - Article
C2 - 34346252
AN - SCOPUS:85112656783
SN - 0301-1526
VL - 50
SP - 439
EP - 445
JO - Vasa - European Journal of Vascular Medicine
JF - Vasa - European Journal of Vascular Medicine
IS - 6
ER -