TY - JOUR
T1 - Association between alcohol consumption trajectories and clinical profiles among women and men living with HIV
AU - Kelso-Chichetto, Natalie E.
AU - Plankey, Michael
AU - Abraham, Alison G.
AU - Ennis, Nicole
AU - Chen, Xinguang
AU - Bolan, Robert
AU - Cook, Robert L.
N1 - Funding Information:
This work was supported by the National Institute of Alcoholism and Alcohol Abuse of the National Institutes of Health (Kelso, F31 AA024064).
Publisher Copyright:
© 2018 Taylor & Francis.
PY - 2018/1/2
Y1 - 2018/1/2
N2 - Background: Alcohol use is common among persons living with HIV (PLWH). It is unclear how alcohol consumption changes over time and if these changes are associated with clinical profiles. Objective: We aimed to describe the association between longitudinal patterns of alcohol consumption and the clinical profiles of PLWH. Methods: Data from the Women’s Interagency HIV Study (n = 1123 women) and Multicenter AIDS Cohort Study (n = 597 men) from 2004 to 2013 were utilized. Group-based trajectory models were used to assess alcohol consumption patterns across 10 years. Generalized estimating equations were used to identify associations between clinical factors and alcohol consumption. All analyses were stratified by sex. Results: Four trajectories of alcohol use were identified in women and men (women: abstinent 38%, low: 25%, moderate: 30%, heavy: 7%; men: abstinent 16%, low: 69%, moderate: 9%, heavy: 5%). The Framingham Risk Score (women: adjusted odds ratio [AOR] 1.07, 95% confidence interval [CI] 1.04–1.09), years on ART (women: AOR 1.02, CI 1.00–1.05; men: AOR 1.05, CI 1.01–1.09), suboptimal ART adherence (men: AOR 1.23, CI 1.07–1.42), and unsuppressed viral load (women: AOR 1.82, CI 1.56–2.13; men: AOR 1.36, CI 1.17–1.58) were associated with increased odds for moderate drinking. The Framingham Risk Score (women: AOR 1.10, CI 1.07–1.14; men: AOR 1.12, CI 1.06–1.20), suboptimal adherence (women: AOR 1.25, CI 1.04–1.51), and unsuppressed viral load (women: AOR 1.78, CI 1.42–2.24) were associated with increased odds for heavy drinking. Conclusions: Clinicians should consider screening patients for alcohol consumption, particularly if patients have comorbid medical conditions, suboptimal antiretroviral adherence, and/or detectable viral load.
AB - Background: Alcohol use is common among persons living with HIV (PLWH). It is unclear how alcohol consumption changes over time and if these changes are associated with clinical profiles. Objective: We aimed to describe the association between longitudinal patterns of alcohol consumption and the clinical profiles of PLWH. Methods: Data from the Women’s Interagency HIV Study (n = 1123 women) and Multicenter AIDS Cohort Study (n = 597 men) from 2004 to 2013 were utilized. Group-based trajectory models were used to assess alcohol consumption patterns across 10 years. Generalized estimating equations were used to identify associations between clinical factors and alcohol consumption. All analyses were stratified by sex. Results: Four trajectories of alcohol use were identified in women and men (women: abstinent 38%, low: 25%, moderate: 30%, heavy: 7%; men: abstinent 16%, low: 69%, moderate: 9%, heavy: 5%). The Framingham Risk Score (women: adjusted odds ratio [AOR] 1.07, 95% confidence interval [CI] 1.04–1.09), years on ART (women: AOR 1.02, CI 1.00–1.05; men: AOR 1.05, CI 1.01–1.09), suboptimal ART adherence (men: AOR 1.23, CI 1.07–1.42), and unsuppressed viral load (women: AOR 1.82, CI 1.56–2.13; men: AOR 1.36, CI 1.17–1.58) were associated with increased odds for moderate drinking. The Framingham Risk Score (women: AOR 1.10, CI 1.07–1.14; men: AOR 1.12, CI 1.06–1.20), suboptimal adherence (women: AOR 1.25, CI 1.04–1.51), and unsuppressed viral load (women: AOR 1.78, CI 1.42–2.24) were associated with increased odds for heavy drinking. Conclusions: Clinicians should consider screening patients for alcohol consumption, particularly if patients have comorbid medical conditions, suboptimal antiretroviral adherence, and/or detectable viral load.
KW - HIV
KW - MACS
KW - WIHS
KW - alcohol use
KW - longitudinal
KW - men
KW - sex
KW - women
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U2 - 10.1080/00952990.2017.1335317
DO - 10.1080/00952990.2017.1335317
M3 - Article
C2 - 28621562
AN - SCOPUS:85020544503
SN - 0095-2990
VL - 44
SP - 85
EP - 94
JO - American Journal of Drug and Alcohol Abuse
JF - American Journal of Drug and Alcohol Abuse
IS - 1
ER -