TY - JOUR
T1 - Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder
AU - Schulze, Thomas G.
AU - Müller, Daniel J.
AU - Krauss, Harald
AU - Scherk, Harald
AU - Ohlraun, Stephanie
AU - Syagailo, Yana V.
AU - Windemuth, Christine
AU - Neidt, Helge
AU - Grässle, Markus
AU - Papassotiropoulos, Andreas
AU - Heun, Reinhard
AU - Nöthen, Markus M.
AU - Maier, Wolfgang
AU - Lesch, Klaus Peter
AU - Rietschel, Marcella
PY - 2000/12/4
Y1 - 2000/12/4
N2 - Various polymorphisms of the X-chromosomal monoamine oxidase A (MAO-A) gene were investigated for association with affecrive disorders. However, none of the studied variants could consistently be associated with either major depressive or bipolar affective disorder. Recently, a positive association between panic disorder and a novel functional repeat polymorphism in the MAO-A gene promoter, with the longer alleles being more active, was reported. Since monoaminergic neurotransmission is supposed to play an important role in affective disorders, we investigated a potential association of this polymorphism with major depressive illness in a sample of 146 unrelated patients of German descent and a control group of 101 individuals with a negative life history for affective disorders. Similarly to the recent findings in panic disorder, we observed a significantly increased frequency of genotypes containing only long alleles in female patients with recurrent major depression in comparison with age- and sex-matched controls. Thus, our data suggest that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for major depressive disorder in females. (C) 2000 Wiley-Liss, Inc.
AB - Various polymorphisms of the X-chromosomal monoamine oxidase A (MAO-A) gene were investigated for association with affecrive disorders. However, none of the studied variants could consistently be associated with either major depressive or bipolar affective disorder. Recently, a positive association between panic disorder and a novel functional repeat polymorphism in the MAO-A gene promoter, with the longer alleles being more active, was reported. Since monoaminergic neurotransmission is supposed to play an important role in affective disorders, we investigated a potential association of this polymorphism with major depressive illness in a sample of 146 unrelated patients of German descent and a control group of 101 individuals with a negative life history for affective disorders. Similarly to the recent findings in panic disorder, we observed a significantly increased frequency of genotypes containing only long alleles in female patients with recurrent major depression in comparison with age- and sex-matched controls. Thus, our data suggest that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for major depressive disorder in females. (C) 2000 Wiley-Liss, Inc.
KW - Functional polymorphism
KW - Major depressive disorder
KW - Monoamine oxidase A gene
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M3 - Article
C2 - 11121185
AN - SCOPUS:0034606330
SN - 1552-4841
VL - 96
SP - 801
EP - 803
JO - American Journal of Medical Genetics - Neuropsychiatric Genetics
JF - American Journal of Medical Genetics - Neuropsychiatric Genetics
IS - 6
ER -