Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda

Alyssa Vecchio; Gertrude Nakigozi; Noeline Nakasujja; Alice Kisakye; James Batte; Richard Mayanja; Aggrey Anok; Kevin Robertson; Maria J. Wawer; Ned Sacktor; Leah H. Rubin; Deanna Saylor

doi:10.1007/s13365-021-00969-x

Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda

Alyssa Vecchio
, Gertrude Nakigozi
, Noeline Nakasujja
, Alice Kisakye
, James Batte
, Richard Mayanja
, Aggrey Anok
, Kevin Robertson
, Maria J. Wawer
, Ned Sacktor
, Leah H. Rubin
, Deanna Saylor

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p <.001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.

Original language	English (US)
Pages (from-to)	487-492
Number of pages	6
Journal	Journal of neurovirology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1007/s13365-021-00969-x
State	Published - Jun 2021

Keywords

ART
Frailty
Global Health
HIV
Neuropsychology
Uganda

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

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10.1007/s13365-021-00969-x

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title = "Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda",

abstract = "We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47\% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19\%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p <.001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.",

keywords = "ART, Frailty, Global Health, HIV, Neuropsychology, Uganda",

author = "Alyssa Vecchio and Gertrude Nakigozi and Noeline Nakasujja and Alice Kisakye and James Batte and Richard Mayanja and Aggrey Anok and Kevin Robertson and Wawer, \{Maria J.\} and Ned Sacktor and Rubin, \{Leah H.\} and Deanna Saylor",

note = "Funding Information: This study was sponsored by the NIH (MH099733, MH075673, MH080661-08, L30NS088658, NS065729-05S2, P30MH075773, P30AI094189-01A1) with additional funding from the Johns Hopkins Center for Global Health and a World Federation of Neurology Grantsin-Aid. Publisher Copyright: {\textcopyright} 2021, Journal of NeuroVirology, Inc.",

year = "2021",

month = jun,

doi = "10.1007/s13365-021-00969-x",

language = "English (US)",

volume = "27",

pages = "487--492",

journal = "Journal of neurovirology",

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AU - Vecchio, Alyssa

AU - Nakigozi, Gertrude

AU - Nakasujja, Noeline

AU - Kisakye, Alice

AU - Batte, James

AU - Mayanja, Richard

AU - Anok, Aggrey

AU - Robertson, Kevin

AU - Wawer, Maria J.

AU - Sacktor, Ned

AU - Rubin, Leah H.

AU - Saylor, Deanna

N1 - Funding Information: This study was sponsored by the NIH (MH099733, MH075673, MH080661-08, L30NS088658, NS065729-05S2, P30MH075773, P30AI094189-01A1) with additional funding from the Johns Hopkins Center for Global Health and a World Federation of Neurology Grantsin-Aid. Publisher Copyright: © 2021, Journal of NeuroVirology, Inc.

PY - 2021/6

Y1 - 2021/6

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AB - We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p <.001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.

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Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda

Abstract

Keywords

ASJC Scopus subject areas

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