Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda

Alyssa Vecchio; Gertrude Nakigozi; Noeline Nakasujja; Alice Kisakye; James Batte; Richard Mayanja; Aggrey Anok; Kevin Robertson; Maria J. Wawer; Ned Sacktor; Leah H. Rubin; Deanna Saylor

doi:10.1007/s13365-021-00969-x

Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda

Alyssa Vecchio, Gertrude Nakigozi, Noeline Nakasujja, Alice Kisakye, James Batte, Richard Mayanja, Aggrey Anok, Kevin Robertson, Maria J. Wawer, Ned Sacktor, Leah H. Rubin, Deanna Saylor

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p <.001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.

Original language	English (US)
Pages (from-to)	487-492
Number of pages	6
Journal	Journal of neurovirology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1007/s13365-021-00969-x
State	Published - Jun 2021

Keywords

ART
Frailty
Global Health
HIV
Neuropsychology
Uganda

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

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10.1007/s13365-021-00969-x

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title = "Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda",

abstract = "We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p <.001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.",

keywords = "ART, Frailty, Global Health, HIV, Neuropsychology, Uganda",

author = "Alyssa Vecchio and Gertrude Nakigozi and Noeline Nakasujja and Alice Kisakye and James Batte and Richard Mayanja and Aggrey Anok and Kevin Robertson and Wawer, {Maria J.} and Ned Sacktor and Rubin, {Leah H.} and Deanna Saylor",

note = "Funding Information: This study was sponsored by the NIH (MH099733, MH075673, MH080661-08, L30NS088658, NS065729-05S2, P30MH075773, P30AI094189-01A1) with additional funding from the Johns Hopkins Center for Global Health and a World Federation of Neurology Grantsin-Aid. Publisher Copyright: {\textcopyright} 2021, Journal of NeuroVirology, Inc.",

year = "2021",

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doi = "10.1007/s13365-021-00969-x",

language = "English (US)",

volume = "27",

pages = "487--492",

journal = "Journal of neurovirology",

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AU - Vecchio, Alyssa

AU - Nakigozi, Gertrude

AU - Nakasujja, Noeline

AU - Kisakye, Alice

AU - Batte, James

AU - Mayanja, Richard

AU - Anok, Aggrey

AU - Robertson, Kevin

AU - Wawer, Maria J.

AU - Sacktor, Ned

AU - Rubin, Leah H.

AU - Saylor, Deanna

N1 - Funding Information: This study was sponsored by the NIH (MH099733, MH075673, MH080661-08, L30NS088658, NS065729-05S2, P30MH075773, P30AI094189-01A1) with additional funding from the Johns Hopkins Center for Global Health and a World Federation of Neurology Grantsin-Aid. Publisher Copyright: © 2021, Journal of NeuroVirology, Inc.

PY - 2021/6

Y1 - 2021/6

N2 - We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p <.001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.

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Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda

Abstract

Keywords

ASJC Scopus subject areas

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