Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda

Alyssa Vecchio, Gertrude Nakigozi, Noeline Nakasujja, Alice Kisakye, James Batte, Richard Mayanja, Aggrey Anok, Kevin Robertson, Maria J. Wawer, Ned Sacktor, Leah H. Rubin, Deanna Saylor

Research output: Contribution to journalArticlepeer-review


We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p <.001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.

Original languageEnglish (US)
Pages (from-to)487-492
Number of pages6
JournalJournal of neurovirology
Issue number3
StatePublished - Jun 2021


  • ART
  • Frailty
  • Global Health
  • HIV
  • Neuropsychology
  • Uganda

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology


Dive into the research topics of 'Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda'. Together they form a unique fingerprint.

Cite this