TY - JOUR
T1 - Assessment of vitamin A status with the relative-dose-response test in Peruvian children recovering from pneumonia
AU - Stephensen, Charles B.
AU - Franchi, Luis Miguel
AU - Hernandez, Herminio
AU - Campos, Miguel
AU - Colarossi, Ana
AU - Gilman, Robert H.
AU - Alvarez, Jose O.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Background: The relative-dose-response (RDR) test is used to identify subjects with marginal liver vitamin A stores, but its use has not been evaluated during episodes of infection. Objective: The objective was to assess, with the RDR test, the vitamin A status of children recovering from pneumonia. Design: As part of a double-blind, placebo-controlled clinical trial of high-dose vitamin A supplements among children hospitalized with pneumonia in Lima, Peru, we examined the association of treatment group, nutritional status, severity of disease, and induction of the acute phase response [on the basis of serum C-reactive protein (CRP)] on serum retinol and the RDR test. Results: Serum retinol was low at admission and increased significantly in both the vitamin A and placebo groups during recovery. Serum CRP had a significant, inverse association with retinol at both admission and discharge. Serum retinol and CRP concentrations never differed significantly between the treatment groups. Among subjects with CRP ≥ 10 mg/L, 21% in the vitamin A group and 20% in the placebo groups (P = 0.83) had a positive RDR test result. Among subjects with CRP < 10 mg/L, 56% in the placebo group but only 6% in the vitamin A group had positive RDR test results (P = 0.002). Conclusion: The RDR test was useful in assessing the vitamin A status of children recovering from pneumonia when CRP concentrations were < 10 mg/L but not when CRP concentrations were higher.
AB - Background: The relative-dose-response (RDR) test is used to identify subjects with marginal liver vitamin A stores, but its use has not been evaluated during episodes of infection. Objective: The objective was to assess, with the RDR test, the vitamin A status of children recovering from pneumonia. Design: As part of a double-blind, placebo-controlled clinical trial of high-dose vitamin A supplements among children hospitalized with pneumonia in Lima, Peru, we examined the association of treatment group, nutritional status, severity of disease, and induction of the acute phase response [on the basis of serum C-reactive protein (CRP)] on serum retinol and the RDR test. Results: Serum retinol was low at admission and increased significantly in both the vitamin A and placebo groups during recovery. Serum CRP had a significant, inverse association with retinol at both admission and discharge. Serum retinol and CRP concentrations never differed significantly between the treatment groups. Among subjects with CRP ≥ 10 mg/L, 21% in the vitamin A group and 20% in the placebo groups (P = 0.83) had a positive RDR test result. Among subjects with CRP < 10 mg/L, 56% in the placebo group but only 6% in the vitamin A group had positive RDR test results (P = 0.002). Conclusion: The RDR test was useful in assessing the vitamin A status of children recovering from pneumonia when CRP concentrations were < 10 mg/L but not when CRP concentrations were higher.
KW - Acute phase response
KW - C-reactive protein
KW - CRP
KW - Children
KW - Peru
KW - Pneumonia
KW - RDR test
KW - Relative-dose-response test
KW - Retinol
KW - Vitamin A
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U2 - 10.1093/ajcn/76.6.1351
DO - 10.1093/ajcn/76.6.1351
M3 - Article
C2 - 12450903
AN - SCOPUS:18744378854
SN - 0002-9165
VL - 76
SP - 1351
EP - 1357
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 6
ER -