@article{c34127b4efdb4e08bb807039898d721f,
title = "Assessment of the Xpert assay among adult pulmonary tuberculosis suspects with and without diabetes mellitus",
abstract = "SETTING: Pune and Pimpri-Chinchwad Municipal Corporation area, Maharashtra State, India. OBJECTIVE: To assess the sensitivity and specificity of the Xpertw MTB/RIF assay among adults with suspected pulmonary tuberculosis (PTB) and with or without diabetes (DM). D E S I G N: As part of a prospective cohort study, we screened 2359 adults presumed to have PTB with no history of TB. All individuals underwent testing for two sputum smears, culture, Xpert, glycated haemoglobin and fasting blood sugar. We calculated sensitivity and specificity of Xpert by comparing it with TB sputum culture result as a gold standard. R E S U L T S: Among screened individuals, 483 (20%) were diagnosed with DM and 1153 (49%) with pre-DM; 723 (31%) had no DM. Overall sensitivity of Xpert was 96% (95%CI 95-97) and specificity was 91% (95%CI 89-93). Xpert sensitivity was significantly higher among DM group (98%) than in the 'No DM' (95%; P, 0.01) and pre-DM (96%; P, 0.05) groups. Among sputum smear-negative individuals, Xpert sensitivity was higher in the DM group than in the No DM (92% vs. 82%; P ¼ 0.054) and pre-DM group (92% vs. 82%; P ¼ 0.037). C O N C L U S I O N: High sensitivity and specificity of Xpert underscores the need for its rapid scale up for the early detection of TB in settings with a high dual burden of TB and DM.",
keywords = "Blood sugar, Culture, Early detection",
author = "S. Deshmukh and S. Atre and A. Chavan and S. Raskar and T. Sawant and V. Mave and N. Gupte and S. Gaikwad and T. Sahasrabudhe and M. Barthwal and A. Kakrani and A. Kagal and A. Gupta and R. Bharadwaj and N. Pradhan and S. Dharmshale and J. Golub",
note = "Funding Information: The authors thank all the staff members at Byramjee Jeejeebhoy Medical College and Sassoon General Hospital, Pune, and Dr D Y Patil Medical College, Pune, India, for their contribution to this study; all the study participants, without whose support the study would not have been possible; and the local RNTCP staff for their cooperation. This work was supported by the National Institutes of Health (Bethesda, MD, USA; NIH 1R01A1I097494-01A1 to JG) and NIH grant number UM1AI069465) for Johns Hopkins Baltimore-Washington-India Clinical Trials Unit for Byramjee Jeejeebhoy Government Medical College HIV Clinical Trials Site. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the funders. The data used for the present study are available with AC and can be provided on reasonable request. Funding Information: This work was supported by the National Institutes of Health (Bethesda, MD, USA; NIH 1R01A1I097494-01A1 to JG) and NIH grant number UM1AI069465) for Johns Hopkins Baltimore-Washington-India Clinical Trials Unit for Byramjee Jeejeebhoy Government Medical College HIV Clinical Trials Site. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the funders. Publisher Copyright: {\textcopyright} 2020 International Union against Tubercul. and Lung Dis.. All rights reserved.",
year = "2020",
month = jan,
day = "1",
doi = "10.5588/ijtld.19.0239",
language = "English (US)",
volume = "24",
pages = "113--117",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "1",
}