Assessment of [11C]-L-methionine transport into the human brain

L. A. O'Tuama, T. R. Guilarte, K. H. Douglass, H. N. Wagner, Dean Foster Wong, R. F. Dannals, Hayden T Ravert, A. A. Wilson, N. D. LaFrance, A. N. Bice, J. M. Links

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Neutral amino acid transport into human brain was measured using a dual-probe positron detection system or positron emission tomography (PET). Rate constants (ml/min/cc) for brain accumulation of [11C]L-methionine measured with the dual detector ranged from 0.012 to 0.078 (average 0.031) under baseline conditions and from 0.010 to 0.017 (average 0.014) after administration of nonradioactive L-phenylalanine (100 mg/kg). The net rate of brain accumulation of L-methionine ranged from 0.42 to 2.89 (average 1.28) nmol/min/cc, and decreased by 27.5-91.2% (average 53.9%) after L-phenylalanine. PET-estimated accumulation rates (ml/min/cc) of [11C]L-methionine ranged from 0.004 to 0.028 (average 0.016) baseline and from 0.010 to 0.021 (average 0.017) after L-phenylalanine. Initial volumes of distribution (ml/cc) of [11C]L-methionine (dual detector) were 0.044-0.070 (average 0.058) baseline and 0.032-0.074 (average 0.051) after phenylalanine and (PET) 0.026-0.098 (average 0.051) baseline and 0.021-0.061 (average 0.042) after phenylalanine. PET permits more accurate measurement of tracer accumulation by brain, excluding noncerebral regions included in dual-detector measurements. The dual-detector system permits better temporal resolution, facilitating kinetic analysis, and requires only one-for tieth the dose of tracer needed for PET. Multiple studies in the same patients are thus possible at low cost.

Original languageEnglish (US)
Pages (from-to)341-345
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Assessment of [11C]-L-methionine transport into the human brain'. Together they form a unique fingerprint.

Cite this