Aspirin in ET:will twice a day keep thrombosis away?

In this issue of Blood, Rocca et al show that aspirin insensitivity or incomplete platelet inhibition with standard once-per-day low-dose aspirin in patients with essential thrombocythemia (ET) is overcome by twice-per-day dosing of low-dose aspirin without an increase in adverse effects. This presents an attractive strategy for improving vascular outcomes in ET.1.