TY - JOUR
T1 - Aspergillosis in children with cancer
T2 - A 34-year experience
AU - Abbasi, Seema
AU - Shenep, Jerry L.
AU - Hughes, Walter T.
AU - Flynn, Patricia M.
N1 - Funding Information:
Received 21 January 1999; revised 29 June 1999. Financial support: This work was supported in part by Cancer Center Support (CORE) grant CA-21765 from the National Cancer Institute and the American Lebanese Syrian Associated Charities. Reprints or correspondence: Dr. Patricia M. Flynn, Department of Infectious Diseases, St. Jude Children’s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105-2794 ([email protected]).
PY - 1999
Y1 - 1999
N2 - A retrospective review of medical records, microbiology and pathology laboratory records, and nosocomial infection surveillance data was undertaken to describe the experience with culture-documented aspergillus infection in pediatric cancer patients at our facility. Sixty-six patients were identified from a 34-year period. The most common underlying diagnosis was leukemia. Risk factors included neutropenia, immunosuppression, and prior antibiotic therapy. On the basis of clinical presentation, 23 patients were believed to have disseminated disease and 43 to have localized disease. The lung was the most frequently affected organ. Despite aggressive medical and surgical management, overall mortality was 85% within the first year after diagnosis. Patients who presented with disease in sites other than the lungs fared better than patients with initial pulmonary involvement (P = .0014). Aspergillosis continues to be associated with poor outcome. Development of improved medical and adjuvant therapies, including surgery, is warranted.
AB - A retrospective review of medical records, microbiology and pathology laboratory records, and nosocomial infection surveillance data was undertaken to describe the experience with culture-documented aspergillus infection in pediatric cancer patients at our facility. Sixty-six patients were identified from a 34-year period. The most common underlying diagnosis was leukemia. Risk factors included neutropenia, immunosuppression, and prior antibiotic therapy. On the basis of clinical presentation, 23 patients were believed to have disseminated disease and 43 to have localized disease. The lung was the most frequently affected organ. Despite aggressive medical and surgical management, overall mortality was 85% within the first year after diagnosis. Patients who presented with disease in sites other than the lungs fared better than patients with initial pulmonary involvement (P = .0014). Aspergillosis continues to be associated with poor outcome. Development of improved medical and adjuvant therapies, including surgery, is warranted.
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U2 - 10.1086/313445
DO - 10.1086/313445
M3 - Article
C2 - 10524965
AN - SCOPUS:0033512462
SN - 1058-4838
VL - 29
SP - 1210
EP - 1219
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -