Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis

Paul M. Kim; Xin Duan; Alex S. Huang; Cindy Y. Liu; Guo Li Ming; Hongjun Song; Solomon H. Snyder

doi:10.1073/pnas.0914706107

Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis

Paul M. Kim, Xin Duan, Alex S. Huang, Cindy Y. Liu, Guo Li Ming, Hongjun Song, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

D-Aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development andsurvivalofnewbornneuronsandsurvival. BecauseD-aspartate isa potential endogenous ligand for NMDA receptors, the loss of which elicits aphenotype resembling DR depletion,D-aspartate may function as a modulator of adult neurogenesis.

Original language	English (US)
Pages (from-to)	3175-3179
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	107
Issue number	7
DOIs	https://doi.org/10.1073/pnas.0914706107
State	Published - Feb 16 2010

Keywords

Hippocampus
NMDA receptor
Neural progenitor cells
Neuroendocrine
Neuronal development

ASJC Scopus subject areas

General

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10.1073/pnas.0914706107

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abstract = "D-Aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development andsurvivalofnewbornneuronsandsurvival. BecauseD-aspartate isa potential endogenous ligand for NMDA receptors, the loss of which elicits aphenotype resembling DR depletion,D-aspartate may function as a modulator of adult neurogenesis.",

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T1 - Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis

AU - Kim, Paul M.

AU - Duan, Xin

AU - Huang, Alex S.

AU - Liu, Cindy Y.

AU - Ming, Guo Li

AU - Song, Hongjun

AU - Snyder, Solomon H.

PY - 2010/2/16

Y1 - 2010/2/16

N2 - D-Aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development andsurvivalofnewbornneuronsandsurvival. BecauseD-aspartate isa potential endogenous ligand for NMDA receptors, the loss of which elicits aphenotype resembling DR depletion,D-aspartate may function as a modulator of adult neurogenesis.

AB - D-Aspartic acid is abundant in the developing brain. We have identified and cloned mammalian aspartate racemase (DR), which converts L aspartate to D-aspartate and colocalizes with D-aspartate in the brain and neuroendocrine tissues. Depletion of DR by retrovirus-mediated expression of short-hairpin RNA in newborn neurons of the adult hippocampus elicits profound defects in the dendritic development andsurvivalofnewbornneuronsandsurvival. BecauseD-aspartate isa potential endogenous ligand for NMDA receptors, the loss of which elicits aphenotype resembling DR depletion,D-aspartate may function as a modulator of adult neurogenesis.

KW - Hippocampus

KW - NMDA receptor

KW - Neural progenitor cells

KW - Neuroendocrine

KW - Neuronal development

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Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis

Abstract

Keywords

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