Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.
- AR variant v7 (ARv7)
- androgen receptor (AR)
- castration-resistant prostate cancer (CRPC)
ASJC Scopus subject areas
- Cancer Research