ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

Laura Cato; Jonas de Tribolet-Hardy; Irene Lee; Jaice T. Rottenberg; Ilsa Coleman; Diana Melchers; René Houtman; Tengfei Xiao; Wei Li; Takuma Uo; Shihua Sun; Nane C. Kuznik; Bettina Göppert; Fatma Ozgun; Martin E. van Royen; Adriaan B. Houtsmuller; Raga Vadhi; Prakash K. Rao; Lewyn Li; Steven P. Balk; Robert B. Den; Bruce J. Trock; R. Jeffrey Karnes; Robert B. Jenkins; Eric A. Klein; Elai Davicioni; Friederike J. Gruhl; Henry W. Long; X. Shirley Liu; Andrew C.B. Cato; Nathan A. Lack; Peter S. Nelson; Stephen R. Plymate; Anna C. Groner; Myles Brown

doi:10.1016/j.ccell.2019.01.008

ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

Laura Cato, Jonas de Tribolet-Hardy, Irene Lee, Jaice T. Rottenberg, Ilsa Coleman, Diana Melchers, René Houtman, Tengfei Xiao, Wei Li, Takuma Uo, Shihua Sun, Nane C. Kuznik, Bettina Göppert, Fatma Ozgun, Martin E. van Royen, Adriaan B. Houtsmuller, Raga Vadhi, Prakash K. Rao, Lewyn Li, Steven P. BalkRobert B. Den, Bruce J. Trock, R. Jeffrey Karnes, Robert B. Jenkins, Eric A. Klein, Elai Davicioni, Friederike J. Gruhl, Henry W. Long, X. Shirley Liu, Andrew C.B. Cato, Nathan A. Lack, Peter S. Nelson, Stephen R. Plymate, Anna C. Groner, Myles Brown

School of Medicine

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.

Original language	English (US)
Pages (from-to)	401-413.e6
Journal	Cancer cell
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/j.ccell.2019.01.008
State	Published - Mar 18 2019

Keywords

AR variant v7 (ARv7)
androgen receptor (AR)
castration-resistant prostate cancer (CRPC)
transcription

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2019.01.008

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Cato, L., de Tribolet-Hardy, J., Lee, I., Rottenberg, J. T., Coleman, I., Melchers, D., Houtman, R., Xiao, T., Li, W., Uo, T., Sun, S., Kuznik, N. C., Göppert, B., Ozgun, F., van Royen, M. E., Houtsmuller, A. B., Vadhi, R., Rao, P. K., Li, L., ... Brown, M. (2019). ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. Cancer cell, 35(3), 401-413.e6. https://doi.org/10.1016/j.ccell.2019.01.008

Cato, L, de Tribolet-Hardy, J, Lee, I, Rottenberg, JT, Coleman, I, Melchers, D, Houtman, R, Xiao, T, Li, W, Uo, T, Sun, S, Kuznik, NC, Göppert, B, Ozgun, F, van Royen, ME, Houtsmuller, AB, Vadhi, R, Rao, PK, Li, L, Balk, SP, Den, RB, Trock, BJ, Karnes, RJ, Jenkins, RB, Klein, EA, Davicioni, E, Gruhl, FJ, Long, HW, Liu, XS, Cato, ACB, Lack, NA, Nelson, PS, Plymate, SR, Groner, AC & Brown, M 2019, 'ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer', Cancer cell, vol. 35, no. 3, pp. 401-413.e6. https://doi.org/10.1016/j.ccell.2019.01.008

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title = "ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer",

abstract = "Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.",

keywords = "AR variant v7 (ARv7), androgen receptor (AR), castration-resistant prostate cancer (CRPC), transcription",

author = "Laura Cato and {de Tribolet-Hardy}, Jonas and Irene Lee and Rottenberg, {Jaice T.} and Ilsa Coleman and Diana Melchers and Ren{\'e} Houtman and Tengfei Xiao and Wei Li and Takuma Uo and Shihua Sun and Kuznik, {Nane C.} and Bettina G{\"o}ppert and Fatma Ozgun and {van Royen}, {Martin E.} and Houtsmuller, {Adriaan B.} and Raga Vadhi and Rao, {Prakash K.} and Lewyn Li and Balk, {Steven P.} and Den, {Robert B.} and Trock, {Bruce J.} and Karnes, {R. Jeffrey} and Jenkins, {Robert B.} and Klein, {Eric A.} and Elai Davicioni and Gruhl, {Friederike J.} and Long, {Henry W.} and Liu, {X. Shirley} and Cato, {Andrew C.B.} and Lack, {Nathan A.} and Nelson, {Peter S.} and Plymate, {Stephen R.} and Groner, {Anna C.} and Myles Brown",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = mar,

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doi = "10.1016/j.ccell.2019.01.008",

language = "English (US)",

volume = "35",

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AU - Cato, Laura

AU - de Tribolet-Hardy, Jonas

AU - Lee, Irene

AU - Rottenberg, Jaice T.

AU - Coleman, Ilsa

AU - Melchers, Diana

AU - Houtman, René

AU - Xiao, Tengfei

AU - Li, Wei

AU - Uo, Takuma

AU - Sun, Shihua

AU - Kuznik, Nane C.

AU - Göppert, Bettina

AU - Ozgun, Fatma

AU - van Royen, Martin E.

AU - Houtsmuller, Adriaan B.

AU - Vadhi, Raga

AU - Rao, Prakash K.

AU - Li, Lewyn

AU - Balk, Steven P.

AU - Den, Robert B.

AU - Trock, Bruce J.

AU - Karnes, R. Jeffrey

AU - Jenkins, Robert B.

AU - Klein, Eric A.

AU - Davicioni, Elai

AU - Gruhl, Friederike J.

AU - Long, Henry W.

AU - Liu, X. Shirley

AU - Cato, Andrew C.B.

AU - Lack, Nathan A.

AU - Nelson, Peter S.

AU - Plymate, Stephen R.

AU - Groner, Anna C.

AU - Brown, Myles

PY - 2019/3/18

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N2 - Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.

AB - Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.

KW - AR variant v7 (ARv7)

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KW - castration-resistant prostate cancer (CRPC)

KW - transcription

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ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

Abstract

Keywords

ASJC Scopus subject areas

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