Artificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets

Stephanie A. Harmon, Thomas H. Sanford, Sheng Xu, Evrim B. Turkbey, Holger Roth, Ziyue Xu, Dong Yang, Andriy Myronenko, Victoria Anderson, Amel Amalou, Maxime Blain, Michael Kassin, Dilara Long, Nicole Varble, Stephanie M. Walker, Ulas Bagci, Anna Maria Ierardi, Elvira Stellato, Guido Giovanni Plensich, Giuseppe FranceschelliCristiano Girlando, Giovanni Irmici, Dominic Labella, Dima Hammoud, Ashkan Malayeri, Elizabeth Jones, Ronald M. Summers, Peter L. Choyke, Daguang Xu, Mona Flores, Kaku Tamura, Hirofumi Obinata, Hitoshi Mori, Francesca Patella, Maurizio Cariati, Gianpaolo Carrafiello, Peng An, Bradford J. Wood, Baris Turkbey

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Artificial intelligence (AI) has the potential to aid in rapid evaluation of CT scans for differentiation of COVID-19 findings from other clinical entities. Here we show that a series of deep learning algorithms, trained in a diverse multinational cohort of 1280 patients to localize parietal pleura/lung parenchyma followed by classification of COVID-19 pneumonia, can achieve up to 90.8% accuracy, with 84% sensitivity and 93% specificity, as evaluated in an independent test set (not included in training and validation) of 1337 patients. Normal controls included chest CTs from oncology, emergency, and pneumonia-related indications. The false positive rate in 140 patients with laboratory confirmed other (non COVID-19) pneumonias was 10%. AI-based algorithms can readily identify CT scans with COVID-19 associated pneumonia, as well as distinguish non-COVID related pneumonias with high specificity in diverse patient populations.

Original languageEnglish (US)
Article number4080
JournalNature communications
Issue number1
StatePublished - Dec 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy


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