TY - JOUR
T1 - Artificial antigen-presenting cells
T2 - Artificial solutions for real diseases
AU - Oelke, Mathias
AU - Krueger, Christine
AU - Giuntoli, Robert L.
AU - Schneck, Jonathan P.
PY - 2005/9
Y1 - 2005/9
N2 - Adoptive immunotherapy, which involves the transfer of autologous antigen-specific T cells generated ex vivo, is a promising strategy to treat a variety of life-threatening diseases. Unfortunately, current approaches for generating sufficient numbers of antigen-specific T cells lack the ability to serve as reproducible and economically viable methods. This has spurred the development of both cell- and non-cell-based artificial antigen-presenting cells to alleviate problems associated with peptide-loaded dendritic cells in current approaches to adoptive immunotherapy. Here, we review new strategies for the ex vivo generation of antigen-specific T cells and their clinical application. These new approaches have the potential to spearhead a new era of successful adoptive immunotherapy for cancer and infectious diseases.
AB - Adoptive immunotherapy, which involves the transfer of autologous antigen-specific T cells generated ex vivo, is a promising strategy to treat a variety of life-threatening diseases. Unfortunately, current approaches for generating sufficient numbers of antigen-specific T cells lack the ability to serve as reproducible and economically viable methods. This has spurred the development of both cell- and non-cell-based artificial antigen-presenting cells to alleviate problems associated with peptide-loaded dendritic cells in current approaches to adoptive immunotherapy. Here, we review new strategies for the ex vivo generation of antigen-specific T cells and their clinical application. These new approaches have the potential to spearhead a new era of successful adoptive immunotherapy for cancer and infectious diseases.
UR - http://www.scopus.com/inward/record.url?scp=24344501661&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24344501661&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2005.07.005
DO - 10.1016/j.molmed.2005.07.005
M3 - Review article
C2 - 16103011
AN - SCOPUS:24344501661
SN - 1471-4914
VL - 11
SP - 412
EP - 420
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 9
ER -