Arthrocentesis and Joint Injection in Patients Receiving Direct Oral Anticoagulants

Jennifer C. Yui, Carina Preskill, Laura S. Greenlund

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Anticoagulation is common in patients undergoing arthrocentesis and joint injections. Previous studies have established the safety of continuing anticoagulation with warfarin before joint aspirations/injections with only a small increased risk of bleeding, but no data are available regarding the use of direct oral anticoagulants (DOACs) and joint aspirations/injections. The objective of this study was to determine the rate of bleeding complications associated with arthrocentesis and joint injection in patients receiving DOACs. We performed a retrospective review of adult patients at Mayo Clinic in Rochester, Minnesota, who were being treated with DOACs and underwent outpatient joint aspiration and/or injection between October 1, 2010, and October 31, 2016. In 1050 consecutive procedures, there were no bleeding complications. Arthrocentesis and joint injections in patients receiving DOAC therapy are safe procedures, and there is no need to withhold anticoagulation treatment before the procedure.

Original languageEnglish (US)
Pages (from-to)1223-1226
Number of pages4
JournalMayo Clinic proceedings
Issue number8
StatePublished - Aug 2017
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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