Arterial-ventricular coupling: Mechanistic insights into cardiovascular performance at rest and during exercise

Understanding the performance of the left ventricle (LV) requires not only examining the properties of the LV itself, but also investigating the modulating effects of the arterial system on left ventricular performance. The interaction of the LV with the arterial system, termed arterial-ventricular coupling (E_A/E_LV), is a central determinant of cardiovascular performance and cardiac energetics. E_A/E_LV can be indexed by the ratio of effective arterial elastance (E_A; a measure of the net arterial load exerted on the left ventricle) to left ventricular end-systolic elastance (E_LV; a load-independent measure of left ventricular chamber performance). At rest, in healthy individuals, E _A/E_LV is maintained within a narrow range, which allows the cardiovascular system to optimize energetic efficiency at the expense of mechanical efficacy. During exercise, an acute mismatch between the arterial and ventricular systems occurs, due to a disproportionate increase in E _LV (from an average of 4.3 to 13.2, and 4.7 to 15.5 mmHg·ml^-1·m^-2 in men and women, respectively) vs. E_A (from an average of 2.3 to 3.2, and 2.3 to 2.9 mmHg·ml^-1·m^-2 in men and women, respectively), to ensure that sufficient cardiac performance is achieved to meet the increased energetic requirements of the body. As a result E _A/E_LV decreases from an average of 0.58 to 0.34, and 0.52 to 0.27 in men and women, respectively. In this review, we provide an overview of the concept of E_A/E_LV, and examine the effects of age, hypertension, and heart failure on E_A/E_LV and its components (E_A and E_LV) in men and women. We discuss these effects both at rest and during exercise and highlight the mechanistic insights that can be derived from studying E_A/E_LV.