Arterial spin-labelling perfusion MRI and outcome in neonates with hypoxic-ischemic encephalopathy

Jill B. De Vis; Jeroen Hendrikse; Esben T. Petersen; Linda S. de Vries; Frank van Bel; Thomas Alderliesten; Simona Negro; Floris Groenendaal; Manon J.N.L. Benders

doi:10.1007/s00330-014-3352-1

Arterial spin-labelling perfusion MRI and outcome in neonates with hypoxic-ischemic encephalopathy

Jill B. De Vis, Jeroen Hendrikse, Esben T. Petersen, Linda S. de Vries, Frank van Bel, Thomas Alderliesten, Simona Negro, Floris Groenendaal, Manon J.N.L. Benders

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Purpose: Hyperperfusion may be related to outcome in neonates with hypoxic-ischemic encephalopathy (HIE). The purpose of this study was to evaluate whether arterial spin labelling (ASL) perfusion is associated with outcome in neonates with HIE and to compare the predictive value of ASL MRI to known MRI predictive markers.

Methods: Twenty-eight neonates diagnosed with HIE and assessed with MR imaging (conventional MRI, diffusion-weighted MRI, MR spectroscopy [MRS], and ASL MRI) were included. Perfusion in the basal ganglia and thalami was measured. Outcome at 9 or 18 months of age was scored as either adverse (death or cerebral palsy) or favourable.

Results: The median (range) perfusion in the basal ganglia and thalami (BGT) was 63 (28-108) ml/100 g/min in the neonates with adverse outcome and 28 (12-51) ml/100 g/min in the infants with favourable outcome (p < 0.01). The area-under-the-curve was 0.92 for ASL MRI, 0.97 for MRI score, 0.96 for Lac/NAA and 0.92 for ADC in the BGT. The combination of Lac/NAA and ASL MRI results was the best predictor of outcome (r² = 0.86, p < 0.001).

Conclusion: Higher ASL perfusion values in neonates with HIE are associated with a worse neurodevelopmental outcome. A combination of the MRS and ASL MRI information is the best predictor of outcome.

Original language	English (US)
Pages (from-to)	113-121
Number of pages	9
Journal	European radiology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1007/s00330-014-3352-1
State	Published - Jan 2015
Externally published	Yes

Keywords

Arterial spin labelling
Hypoxic-ischemic encephalopathy
MRI
Neonate
Perfusion

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s00330-014-3352-1

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@article{a8a6de1e7736428fac1013fc7cafa614,

title = "Arterial spin-labelling perfusion MRI and outcome in neonates with hypoxic-ischemic encephalopathy",

abstract = "Purpose: Hyperperfusion may be related to outcome in neonates with hypoxic-ischemic encephalopathy (HIE). The purpose of this study was to evaluate whether arterial spin labelling (ASL) perfusion is associated with outcome in neonates with HIE and to compare the predictive value of ASL MRI to known MRI predictive markers.Methods: Twenty-eight neonates diagnosed with HIE and assessed with MR imaging (conventional MRI, diffusion-weighted MRI, MR spectroscopy [MRS], and ASL MRI) were included. Perfusion in the basal ganglia and thalami was measured. Outcome at 9 or 18 months of age was scored as either adverse (death or cerebral palsy) or favourable.Results: The median (range) perfusion in the basal ganglia and thalami (BGT) was 63 (28-108) ml/100 g/min in the neonates with adverse outcome and 28 (12-51) ml/100 g/min in the infants with favourable outcome (p < 0.01). The area-under-the-curve was 0.92 for ASL MRI, 0.97 for MRI score, 0.96 for Lac/NAA and 0.92 for ADC in the BGT. The combination of Lac/NAA and ASL MRI results was the best predictor of outcome (r2 = 0.86, p < 0.001).Conclusion: Higher ASL perfusion values in neonates with HIE are associated with a worse neurodevelopmental outcome. A combination of the MRS and ASL MRI information is the best predictor of outcome.",

keywords = "Arterial spin labelling, Hypoxic-ischemic encephalopathy, MRI, Neonate, Perfusion",

author = "{De Vis}, {Jill B.} and Jeroen Hendrikse and Petersen, {Esben T.} and {de Vries}, {Linda S.} and {van Bel}, Frank and Thomas Alderliesten and Simona Negro and Floris Groenendaal and Benders, {Manon J.N.L.}",

note = "Funding Information: The scientific guarantor of this publication is Jill Britt De Vis. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study received funding from the Dutch Technology Foundation STW, Applied Science Division of NWO, the technology program of the Ministry of Economic Affairs, and the ZonMw electromagnetic fields and health program. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: prospective diagnostic or prognostic study, performed at one institution. Publisher Copyright: {\textcopyright} 2014, European Society of Radiology.",

year = "2015",

month = jan,

doi = "10.1007/s00330-014-3352-1",

language = "English (US)",

volume = "25",

pages = "113--121",

journal = "European radiology",

issn = "0938-7994",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Arterial spin-labelling perfusion MRI and outcome in neonates with hypoxic-ischemic encephalopathy

AU - De Vis, Jill B.

AU - Hendrikse, Jeroen

AU - Petersen, Esben T.

AU - de Vries, Linda S.

AU - van Bel, Frank

AU - Alderliesten, Thomas

AU - Negro, Simona

AU - Groenendaal, Floris

AU - Benders, Manon J.N.L.

N1 - Funding Information: The scientific guarantor of this publication is Jill Britt De Vis. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study received funding from the Dutch Technology Foundation STW, Applied Science Division of NWO, the technology program of the Ministry of Economic Affairs, and the ZonMw electromagnetic fields and health program. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: prospective diagnostic or prognostic study, performed at one institution. Publisher Copyright: © 2014, European Society of Radiology.

PY - 2015/1

Y1 - 2015/1

N2 - Purpose: Hyperperfusion may be related to outcome in neonates with hypoxic-ischemic encephalopathy (HIE). The purpose of this study was to evaluate whether arterial spin labelling (ASL) perfusion is associated with outcome in neonates with HIE and to compare the predictive value of ASL MRI to known MRI predictive markers.Methods: Twenty-eight neonates diagnosed with HIE and assessed with MR imaging (conventional MRI, diffusion-weighted MRI, MR spectroscopy [MRS], and ASL MRI) were included. Perfusion in the basal ganglia and thalami was measured. Outcome at 9 or 18 months of age was scored as either adverse (death or cerebral palsy) or favourable.Results: The median (range) perfusion in the basal ganglia and thalami (BGT) was 63 (28-108) ml/100 g/min in the neonates with adverse outcome and 28 (12-51) ml/100 g/min in the infants with favourable outcome (p < 0.01). The area-under-the-curve was 0.92 for ASL MRI, 0.97 for MRI score, 0.96 for Lac/NAA and 0.92 for ADC in the BGT. The combination of Lac/NAA and ASL MRI results was the best predictor of outcome (r2 = 0.86, p < 0.001).Conclusion: Higher ASL perfusion values in neonates with HIE are associated with a worse neurodevelopmental outcome. A combination of the MRS and ASL MRI information is the best predictor of outcome.

AB - Purpose: Hyperperfusion may be related to outcome in neonates with hypoxic-ischemic encephalopathy (HIE). The purpose of this study was to evaluate whether arterial spin labelling (ASL) perfusion is associated with outcome in neonates with HIE and to compare the predictive value of ASL MRI to known MRI predictive markers.Methods: Twenty-eight neonates diagnosed with HIE and assessed with MR imaging (conventional MRI, diffusion-weighted MRI, MR spectroscopy [MRS], and ASL MRI) were included. Perfusion in the basal ganglia and thalami was measured. Outcome at 9 or 18 months of age was scored as either adverse (death or cerebral palsy) or favourable.Results: The median (range) perfusion in the basal ganglia and thalami (BGT) was 63 (28-108) ml/100 g/min in the neonates with adverse outcome and 28 (12-51) ml/100 g/min in the infants with favourable outcome (p < 0.01). The area-under-the-curve was 0.92 for ASL MRI, 0.97 for MRI score, 0.96 for Lac/NAA and 0.92 for ADC in the BGT. The combination of Lac/NAA and ASL MRI results was the best predictor of outcome (r2 = 0.86, p < 0.001).Conclusion: Higher ASL perfusion values in neonates with HIE are associated with a worse neurodevelopmental outcome. A combination of the MRS and ASL MRI information is the best predictor of outcome.

KW - Arterial spin labelling

KW - Hypoxic-ischemic encephalopathy

KW - MRI

KW - Neonate

KW - Perfusion

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JO - European radiology

JF - European radiology

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ER -

Arterial spin-labelling perfusion MRI and outcome in neonates with hypoxic-ischemic encephalopathy

Abstract

Keywords

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