ART adherence, resistance, and long-term HIV viral suppression in postpartum women

Andrew D. Redd; Elton Mukonda; Nai Chung Hu; Tamsin K. Philips; Allison Zerbe; Maia Lesosky; Nei Yuan Hsiao; William Clarke; Steven J. Reynolds; Elaine J. Abrams; Landon Myer

doi:10.1093/ofid/ofaa346

ART adherence, resistance, and long-term HIV viral suppression in postpartum women

Andrew D. Redd, Elton Mukonda, Nai Chung Hu, Tamsin K. Philips, Allison Zerbe, Maia Lesosky, Nei Yuan Hsiao, William Clarke, Steven J. Reynolds, Elaine J. Abrams, Landon Myer

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

HIV+ South African women who achieved viral suppression during routine antenatal care, but later experienced a viremic episode (viral load >1000 copies/mL), were examined for presence of antiretrovirals and classified as “nonadherers” or “suboptimal adherers.” Women were tested for drug resistance mutations (DRMs) at several time points and underwent viral load testing 36–60 months postpartum. Suboptimal adherers were more likely to have DRM detected during their viremic episode (P = .03) and at a subsequent viremic time point (P = .05). There was no difference in levels of viral suppression 36–60 months later in women with DRM detected vs women who had no evidence of DRM (P = .5).

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofaa346
State	Published - Oct 1 2020

Keywords

ART adherence
Atiretrovirals
Drug resistance
Postpartum women

ASJC Scopus subject areas

Oncology
Infectious Diseases

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10.1093/ofid/ofaa346

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title = "ART adherence, resistance, and long-term HIV viral suppression in postpartum women",

abstract = "HIV+ South African women who achieved viral suppression during routine antenatal care, but later experienced a viremic episode (viral load >1000 copies/mL), were examined for presence of antiretrovirals and classified as “nonadherers” or “suboptimal adherers.” Women were tested for drug resistance mutations (DRMs) at several time points and underwent viral load testing 36–60 months postpartum. Suboptimal adherers were more likely to have DRM detected during their viremic episode (P = .03) and at a subsequent viremic time point (P = .05). There was no difference in levels of viral suppression 36–60 months later in women with DRM detected vs women who had no evidence of DRM (P = .5).",

keywords = "ART adherence, Atiretrovirals, Drug resistance, Postpartum women",

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AU - Zerbe, Allison

AU - Lesosky, Maia

AU - Hsiao, Nei Yuan

AU - Clarke, William

AU - Reynolds, Steven J.

AU - Abrams, Elaine J.

AU - Myer, Landon

N1 - Funding Information: This work was supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) through the National Institute of Child Health and Human Development (NICHD; 1R01HD074558 & 1R01HD080465) and in part by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Publisher Copyright: © 2020 Oxford University Press. All rights reserved.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - HIV+ South African women who achieved viral suppression during routine antenatal care, but later experienced a viremic episode (viral load >1000 copies/mL), were examined for presence of antiretrovirals and classified as “nonadherers” or “suboptimal adherers.” Women were tested for drug resistance mutations (DRMs) at several time points and underwent viral load testing 36–60 months postpartum. Suboptimal adherers were more likely to have DRM detected during their viremic episode (P = .03) and at a subsequent viremic time point (P = .05). There was no difference in levels of viral suppression 36–60 months later in women with DRM detected vs women who had no evidence of DRM (P = .5).

AB - HIV+ South African women who achieved viral suppression during routine antenatal care, but later experienced a viremic episode (viral load >1000 copies/mL), were examined for presence of antiretrovirals and classified as “nonadherers” or “suboptimal adherers.” Women were tested for drug resistance mutations (DRMs) at several time points and underwent viral load testing 36–60 months postpartum. Suboptimal adherers were more likely to have DRM detected during their viremic episode (P = .03) and at a subsequent viremic time point (P = .05). There was no difference in levels of viral suppression 36–60 months later in women with DRM detected vs women who had no evidence of DRM (P = .5).

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ART adherence, resistance, and long-term HIV viral suppression in postpartum women

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Keywords

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