TY - JOUR
T1 - Arginine vasopressin
T2 - a novel peptide rhythm in cerebrospinal fluid
AU - Reppert, Steven M.
AU - Schwartz, William J.
AU - Uhl, George R.
PY - 1987
Y1 - 1987
N2 - The neuropeptide, arginine vasopressin, exhibits a prominent daily rhythm in the cerebrospinal fluid (CSF) of several mammals. The CSF rhythm is an endogenously generated, circadian rhythm and is entrained to the 24 h period by the daily light-dark cycle. The circadian regulation of vasopressin in CSF is effectively insulated from the osmotic regulation of the peptide in blood. The CSF vasopressin rhythm is produced by a neural system anatomically separate from the classical hypothalamo-neurohypophyseal system. The suprachiasmatic nuclei, the site of a hypothalamic circadian pacemaker, are an important component of this newly defined neural system and are necessary for rhythm generation. These findings support the concept that brain vasopressin is both functionally and anatomically compartmentalized for specific actions within the CNS.
AB - The neuropeptide, arginine vasopressin, exhibits a prominent daily rhythm in the cerebrospinal fluid (CSF) of several mammals. The CSF rhythm is an endogenously generated, circadian rhythm and is entrained to the 24 h period by the daily light-dark cycle. The circadian regulation of vasopressin in CSF is effectively insulated from the osmotic regulation of the peptide in blood. The CSF vasopressin rhythm is produced by a neural system anatomically separate from the classical hypothalamo-neurohypophyseal system. The suprachiasmatic nuclei, the site of a hypothalamic circadian pacemaker, are an important component of this newly defined neural system and are necessary for rhythm generation. These findings support the concept that brain vasopressin is both functionally and anatomically compartmentalized for specific actions within the CNS.
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U2 - 10.1016/0166-2236(87)90029-4
DO - 10.1016/0166-2236(87)90029-4
M3 - Article
AN - SCOPUS:0003016114
SN - 0166-2236
VL - 10
SP - 76
EP - 80
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 2
ER -