TY - JOUR
T1 - Are proteins made from a limited parts list?
AU - Fitzkee, Nicholas C.
AU - Fleming, Patrick J.
AU - Gong, Haipeng
AU - Panasik, Nicholas
AU - Street, Timothy O.
AU - Rose, George D.
N1 - Funding Information:
We thank L. Mario Amzel, Robert L. Baldwin, Bertrand Garcia-Moreno E. and Ross Shiman for their critical reading of the article. The authors' work is supported by a grant from the Mathers Foundation. We dedicate this article to Robert L. (‘Buzz’) Baldwin, whose insights have been a guiding influence in so very many protein-folding studies, including this one.
PY - 2005/2
Y1 - 2005/2
N2 - Understanding the process of protein folding has been recognized as an important challenge for >70 years. It is, quintessentially, a thermodynamic problem and, arguably, thermodynamics is our most powerful discipline for understanding biological systems. Yet, despite all this, we still lack predictive understanding of protein folding. Is something missing from this picture?
AB - Understanding the process of protein folding has been recognized as an important challenge for >70 years. It is, quintessentially, a thermodynamic problem and, arguably, thermodynamics is our most powerful discipline for understanding biological systems. Yet, despite all this, we still lack predictive understanding of protein folding. Is something missing from this picture?
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U2 - 10.1016/j.tibs.2004.12.005
DO - 10.1016/j.tibs.2004.12.005
M3 - Article
C2 - 15691652
AN - SCOPUS:13244258557
SN - 0968-0004
VL - 30
SP - 73
EP - 80
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 2
ER -