TY - JOUR
T1 - Arachidonic Acid Metabolites During Nasal Challenge
AU - Brown, Mark S.
AU - Peters, Stephen P.
AU - Adkinson, N. Franklin
AU - Proud, David
AU - Kagey-Sobotka, Anne
AU - Norman, Philip S.
AU - Lichtenstein, Lawrence M.
AU - Naclerio, Robert M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1987/2
Y1 - 1987/2
N2 - In order to assess the role of arachidonic acid metabolites in the early reaction to antigen, we challenged six allergic individuals with and without premedication with aspirin and recorded their clinical response, as indicated by number of sneezes, and measured the levels of inflammatory mediators. The early reaction to antigen was associated with increases in the levels of histamine, Na-tosyl-l-arginine methyl esterase (TAME-esterase) activity, prostaglandin (PG) D2, leukotriene C4, PGE, and thromboxane. Aspirin significantly inhibited the increases in the cyclooxygenase metabolites PGE, PGD2, PGF2α, 6-keto-PGF1α, and thromboxane but did not affect the amount of sneezing or the levels of histamine, TAME-esterase activity, or leukotrienes. The pattern of the metabolites and their response to pretreatment with aspirin parallel the response of purified human lung mast cells, supporting the notion that the early phase of allergic rhinitis is a mast cell—dominated event. (Arch Otolaryngol Head Neck Surg 1987;113:179-183)
AB - In order to assess the role of arachidonic acid metabolites in the early reaction to antigen, we challenged six allergic individuals with and without premedication with aspirin and recorded their clinical response, as indicated by number of sneezes, and measured the levels of inflammatory mediators. The early reaction to antigen was associated with increases in the levels of histamine, Na-tosyl-l-arginine methyl esterase (TAME-esterase) activity, prostaglandin (PG) D2, leukotriene C4, PGE, and thromboxane. Aspirin significantly inhibited the increases in the cyclooxygenase metabolites PGE, PGD2, PGF2α, 6-keto-PGF1α, and thromboxane but did not affect the amount of sneezing or the levels of histamine, TAME-esterase activity, or leukotrienes. The pattern of the metabolites and their response to pretreatment with aspirin parallel the response of purified human lung mast cells, supporting the notion that the early phase of allergic rhinitis is a mast cell—dominated event. (Arch Otolaryngol Head Neck Surg 1987;113:179-183)
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U2 - 10.1001/archotol.1987.01860020071015
DO - 10.1001/archotol.1987.01860020071015
M3 - Article
C2 - 3099812
AN - SCOPUS:0023147377
SN - 0886-4470
VL - 113
SP - 179
EP - 183
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 2
ER -