Approaches to pretransplant vaccination

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of reviewThe aim of this study was to summarize new data and perspectives in pretransplant vaccination, with a particular focus on COVID-19 vaccination and vaccination requirements.Recent findingsPretransplant vaccination produces superior markers of immunity and is expected to have greater clinical benefit, compared with posttransplant vaccination. As such, efforts are underway to identify and characterize barriers to pretransplant vaccination, with a particular focus on COVID-19 vaccine hesitancy. Unfortunately, vaccine hesitancy is common in transplant patients, often motivated by individual side effect and safety concerns. COVID-19 vaccination requirements have been implemented in some centres, informed by ethical principles, including beneficence, utility and justice.SummaryBarriers to pretransplant vaccination can be understood in three categories: hard stops, including issues of vaccine availability, eligibility, safety and feasibility; soft stops, including issues of convenience, prioritization and care coordination; and volitional stops related to vaccine hesitancy and refusal. All of these barriers present opportunities for improvement based on recent data.

Original languageEnglish (US)
Pages (from-to)277-284
Number of pages8
JournalCurrent opinion in organ transplantation
Volume27
Issue number4
DOIs
StatePublished - Aug 1 2022

Keywords

  • ethics
  • pretransplant vaccination
  • vaccine hesitancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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