Applications of cryobiopsy in airway, pleural, and parenchymal disease

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Cryobiopsy is a novel diagnostic technique for thoracic diseases, which has been extensively investigated over the past 20 years. It was originally proposed for the diagnosis of endobronchial lesions and diffuse parenchymal lung disease due to limitations of conventional sampling techniques including small size and presence of artifacts. Areas covered: We review recent evidence related to the expanding use of cryobiopsy in thoracic diseases. To identify references, the MEDLINE database was searched from database inception until May 2022 for case series, cohort studies, randomized controlled trials, systematic reviews, and meta-analyses related to cryobiopsy. Expert opinion: Cryobiopsy has expanding applications in the field of thoracic diseases. Evidence to support transbronchial cryobiopsy as an alternative to surgical lung biopsy is increasing and was recently endorsed as a conditional recommendation by the latest American Thoracic Society guideline update for Idiopathic Pulmonary Fibrosis. Developments in technology and technique, in particular the availability of a 1.1 mm flexible cryoprobe, have extended applications to pulmonary diseases, including diagnosis of interstitial lung diseases, peripheral pulmonary lesions, and lung transplant rejection.

Original languageEnglish (US)
Pages (from-to)875-886
Number of pages12
JournalExpert review of respiratory medicine
Volume16
Issue number8
DOIs
StatePublished - 2022

Keywords

  • Cryobiopsy
  • bronchoscopy
  • endobronchial ultrasound
  • thoracoscopy
  • transbronchial biopsy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

Fingerprint

Dive into the research topics of 'Applications of cryobiopsy in airway, pleural, and parenchymal disease'. Together they form a unique fingerprint.

Cite this