Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas

Shanshan Jiang, Zhibo Wen, Sung Soo Ahn, Kejia Cai, Daniel Paech, Charles G. Eberhart, Jinyuan Zhou

Research output: Contribution to journalReview articlepeer-review

Abstract

Chemical exchange saturation transfer (CEST) imaging is an important molecular magnetic resonance imaging technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. CEST, or more specially amide proton transfer-weighted imaging, has been widely used for the detection, diagnosis, and response assessment of brain tumors, and its feasibility in identifying molecular markers in gliomas has also been explored in recent years. In this paper, after briefing on the basic principles and quantification methods of CEST imaging, we review its early applications in identifying isocitrate dehydrogenase mutation status, MGMT methylation status, 1p/19q deletion status, and H3K27M mutation status in gliomas. Finally, we discuss the limitations or weaknesses in these studies.

Original languageEnglish (US)
Article numbere4731
JournalNMR in biomedicine
Volume36
Issue number6
DOIs
StatePublished - Jun 2023

Keywords

  • 1p19q
  • APTw imaging
  • CEST imaging
  • IDH mutation
  • glioma

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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