Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas

Shanshan Jiang; Zhibo Wen; Sung Soo Ahn; Kejia Cai; Daniel Paech; Charles G. Eberhart; Jinyuan Zhou

doi:10.1002/nbm.4731

Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas

Shanshan Jiang, Zhibo Wen, Sung Soo Ahn, Kejia Cai, Daniel Paech, Charles G. Eberhart, Jinyuan Zhou

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Chemical exchange saturation transfer (CEST) imaging is an important molecular magnetic resonance imaging technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. CEST, or more specially amide proton transfer-weighted imaging, has been widely used for the detection, diagnosis, and response assessment of brain tumors, and its feasibility in identifying molecular markers in gliomas has also been explored in recent years. In this paper, after briefing on the basic principles and quantification methods of CEST imaging, we review its early applications in identifying isocitrate dehydrogenase mutation status, MGMT methylation status, 1p/19q deletion status, and H3K27M mutation status in gliomas. Finally, we discuss the limitations or weaknesses in these studies.

Original language	English (US)
Article number	e4731
Journal	NMR in biomedicine
Volume	36
Issue number	6
DOIs	https://doi.org/10.1002/nbm.4731
State	Published - Jun 2023

Keywords

1p19q
APTw imaging
CEST imaging
IDH mutation
glioma

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Spectroscopy

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10.1002/nbm.4731

Cite this

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title = "Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas",

abstract = "Chemical exchange saturation transfer (CEST) imaging is an important molecular magnetic resonance imaging technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. CEST, or more specially amide proton transfer-weighted imaging, has been widely used for the detection, diagnosis, and response assessment of brain tumors, and its feasibility in identifying molecular markers in gliomas has also been explored in recent years. In this paper, after briefing on the basic principles and quantification methods of CEST imaging, we review its early applications in identifying isocitrate dehydrogenase mutation status, MGMT methylation status, 1p/19q deletion status, and H3K27M mutation status in gliomas. Finally, we discuss the limitations or weaknesses in these studies.",

keywords = "1p19q, APTw imaging, CEST imaging, IDH mutation, glioma",

author = "Shanshan Jiang and Zhibo Wen and Ahn, {Sung Soo} and Kejia Cai and Daniel Paech and Eberhart, {Charles G.} and Jinyuan Zhou",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.",

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AU - Jiang, Shanshan

AU - Wen, Zhibo

AU - Ahn, Sung Soo

AU - Cai, Kejia

AU - Paech, Daniel

AU - Eberhart, Charles G.

AU - Zhou, Jinyuan

PY - 2023/6

Y1 - 2023/6

N2 - Chemical exchange saturation transfer (CEST) imaging is an important molecular magnetic resonance imaging technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. CEST, or more specially amide proton transfer-weighted imaging, has been widely used for the detection, diagnosis, and response assessment of brain tumors, and its feasibility in identifying molecular markers in gliomas has also been explored in recent years. In this paper, after briefing on the basic principles and quantification methods of CEST imaging, we review its early applications in identifying isocitrate dehydrogenase mutation status, MGMT methylation status, 1p/19q deletion status, and H3K27M mutation status in gliomas. Finally, we discuss the limitations or weaknesses in these studies.

AB - Chemical exchange saturation transfer (CEST) imaging is an important molecular magnetic resonance imaging technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. CEST, or more specially amide proton transfer-weighted imaging, has been widely used for the detection, diagnosis, and response assessment of brain tumors, and its feasibility in identifying molecular markers in gliomas has also been explored in recent years. In this paper, after briefing on the basic principles and quantification methods of CEST imaging, we review its early applications in identifying isocitrate dehydrogenase mutation status, MGMT methylation status, 1p/19q deletion status, and H3K27M mutation status in gliomas. Finally, we discuss the limitations or weaknesses in these studies.

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KW - CEST imaging

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KW - glioma

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Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas

Abstract

Keywords

ASJC Scopus subject areas

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