TY - JOUR
T1 - Application of the Milan System for Reporting Salivary Gland Cytopathology in pediatric patients
T2 - An international, multi-institutional study
AU - Maleki, Zahra
AU - Saoud, Carla
AU - Viswanathan, Kartik
AU - Kilic, Irem
AU - Tommola, Erkka
AU - Griffin, Daniel T.
AU - Heider, Amer
AU - Petrone, Gianluigi
AU - Jo, Vickie Y.
AU - Centeno, Barbara A.
AU - Saieg, Mauro
AU - Mikou, Panagiota
AU - Fadda, Guido
AU - Ali, Syed Z.
AU - Kholová, Ivana
AU - Wojcik, Eva M.
AU - Barkan, Güliz A.
AU - Eisele, David W.
AU - Bellevicine, Claudio
AU - Vigliar, Elena
AU - Wiles, Austin B.
AU - Al-Ibraheemi, Alyaa
AU - Allison, Derek B.
AU - Dixon, Glen R.
AU - Chandra, Ashish
AU - Walsh, Jonathan M.
AU - Baloch, Zubair W.
AU - Faquin, William C.
AU - Krane, Jeffrey F.
AU - Rossi, Esther Diana
AU - Pantanowitz, Liron
AU - Troncone, Giancarlo
AU - Callegari, Fabiano M.
AU - Klijanienko, Jerzy
N1 - Publisher Copyright:
© 2022 American Cancer Society.
PY - 2022/5
Y1 - 2022/5
N2 - BACKGROUND: Pediatric salivary gland fine-needle aspiration (FNA) is uncommon with a higher frequency of inflammatory lesions and a small proportion of malignancies. This international, multi-institutional cohort evaluated the application of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) and the risk of malignancy (ROM) for each diagnostic category. METHODS: Pediatric (0- to 21-year-old) salivary gland FNA specimens from 22 international institutions of 7 countries, including the United States, England, Italy, Greece, Finland, Brazil, and France, were retrospectively assigned to an MSRSGC diagnostic category as follows: nondiagnostic, nonneoplastic, atypia of undetermined significance (AUS), benign neoplasm, salivary gland neoplasm of uncertain malignant potential (SUMP), suspicious for malignancy (SM), or malignant. Cytology-histology correlation was performed where available, and the ROM was calculated for each MSRSGC diagnostic category. RESULTS: The cohort of 477 aspirates was reclassified according to the MSRSGC as follows: nondiagnostic, 10.3%; nonneoplastic, 34.6%; AUS, 5.2%; benign neoplasm, 27.5%; SUMP, 7.5%; SM, 2.5%; and malignant, 12.4%. Histopathologic follow-up was available for 237 cases (49.7%). The ROMs were as follows: nondiagnostic, 5.9%; nonneoplastic, 9.1%; AUS, 35.7%; benign neoplasm, 3.3%; SUMP, 31.8%; SM, 100%; and malignant, 100%. Mucoepidermoid carcinoma was the most common malignancy (18 of 237; 7.6%), and it was followed by acinic cell carcinoma (16 of 237; 6.8%). Pleomorphic adenoma was the most common benign neoplasm (95 of 237; 40.1%). CONCLUSIONS: The MSRSGC can be reliably applied to pediatric salivary gland FNA. The ROM of each MSRSGC category in pediatric salivary gland FNA is relatively similar to the ROM of each category in adult salivary gland FNA, although the reported rates for the different MSRSGC categories are variable across institutions.
AB - BACKGROUND: Pediatric salivary gland fine-needle aspiration (FNA) is uncommon with a higher frequency of inflammatory lesions and a small proportion of malignancies. This international, multi-institutional cohort evaluated the application of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) and the risk of malignancy (ROM) for each diagnostic category. METHODS: Pediatric (0- to 21-year-old) salivary gland FNA specimens from 22 international institutions of 7 countries, including the United States, England, Italy, Greece, Finland, Brazil, and France, were retrospectively assigned to an MSRSGC diagnostic category as follows: nondiagnostic, nonneoplastic, atypia of undetermined significance (AUS), benign neoplasm, salivary gland neoplasm of uncertain malignant potential (SUMP), suspicious for malignancy (SM), or malignant. Cytology-histology correlation was performed where available, and the ROM was calculated for each MSRSGC diagnostic category. RESULTS: The cohort of 477 aspirates was reclassified according to the MSRSGC as follows: nondiagnostic, 10.3%; nonneoplastic, 34.6%; AUS, 5.2%; benign neoplasm, 27.5%; SUMP, 7.5%; SM, 2.5%; and malignant, 12.4%. Histopathologic follow-up was available for 237 cases (49.7%). The ROMs were as follows: nondiagnostic, 5.9%; nonneoplastic, 9.1%; AUS, 35.7%; benign neoplasm, 3.3%; SUMP, 31.8%; SM, 100%; and malignant, 100%. Mucoepidermoid carcinoma was the most common malignancy (18 of 237; 7.6%), and it was followed by acinic cell carcinoma (16 of 237; 6.8%). Pleomorphic adenoma was the most common benign neoplasm (95 of 237; 40.1%). CONCLUSIONS: The MSRSGC can be reliably applied to pediatric salivary gland FNA. The ROM of each MSRSGC category in pediatric salivary gland FNA is relatively similar to the ROM of each category in adult salivary gland FNA, although the reported rates for the different MSRSGC categories are variable across institutions.
KW - Milan System for Reporting Salivary Gland Cytology (MSRSGC)
KW - cytology
KW - fine-needle aspiration
KW - parotid
KW - pediatric cytology
KW - risk of malignancy
KW - salivary gland
KW - submandibular gland
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U2 - 10.1002/cncy.22556
DO - 10.1002/cncy.22556
M3 - Article
C2 - 35081269
AN - SCOPUS:85123579831
SN - 1934-662X
VL - 130
SP - 370
EP - 380
JO - Cancer Cytopathology
JF - Cancer Cytopathology
IS - 5
ER -