Application of statistical cancer atlas for 3D biopsy

Ramkrishnan Narayanan, Dinggang Shen, Christos Davatzikos, E. David Crawford, Albaha Barqawi, Priya Werahera, Dinesh Kumar, Jasjit S. Suri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Prostate cancer is the most commonly diagnosed cancer in males in the United States and the second leading cause of cancer death. While the exact cause is still under investigation, researchers agree on certain risk factors like age, family history, dietary habits, lifestyle and race. It is also widely accepted that cancer distribution within the prostate is inhomogeneous, i.e. certain regions have a higher likelihood of developing cancer. In this regard extensive work has been done to study the distribution of cancer in order to perform biopsy more effectively. Recently a statistical cancer atlas of the prostate was demonstrated along with an optimal biopsy scheme achieving a high detection rate. In this paper we discuss the complete construction and application of such an atlas that can be used in a clinical setting to effectively target high cancer zones during biopsy. The method consists of integrating intensity statistics in the form of cancer probabilities at every voxel in the image with shape statistics of the prostate in order to quickly warp the atlas onto a subject ultrasound image. While the atlas surface can be registered to a pre-segmented subject prostate surface or instead used to perform segmentation of the capsule via optimization of shape parameters to segment the subject image, the strength of our approach lies in the fast mapping of cancer statistics onto the subject using shape statistics. The shape model was trained from over 38 expert segmented prostate surfaces and the atlas registration accuracy was found to be high suggesting the use of this method to perform biopsy in near real time situations with some optimization.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE-IS and T Electronic Imaging -Image Processing
Subtitle of host publicationAlgorithms and Systems VI
StatePublished - 2008
Externally publishedYes
EventImage Processing: Algorithms and Systems VI - San Jose, CA, United States
Duration: Jan 28 2008Jan 29 2008

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherImage Processing: Algorithms and Systems VI
Country/TerritoryUnited States
CitySan Jose, CA


  • Atlas
  • Cancer
  • Prostate
  • Registration
  • Shape

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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