TY - GEN
T1 - Application of post reconstruction dual respiratory and cardiac motion compensation for 4D high-resolution small animal myocardial SPECT
AU - Lee, Taek Soo
AU - Rittenbach, Andrew
AU - Feng, Tao
AU - Tsui, Benjamin M.W.
N1 - Funding Information:
This work was supported by NIH grants R01 EB 000168, R01 HL 068075, and R01 EB 000121
Publisher Copyright:
© 2015 IEEE.
PY - 2016/10/3
Y1 - 2016/10/3
N2 - We investigated the performance of a post reconstruction dual respiratory and cardiac (R&C) motion compensation method for improved image quality of 4D cardiac gated small animal myocardial perfusion (MP) SPECT images. A normal mouse was injected with ∼8 mCi of Tc-99m sestamibi, anesthetized, fitted with ECG leads for cardiac gating signal acquisition, and placed on top of a pressure gauge bellow for respiratory motion measurements. A 2-hour list-mode dataset was acquired using a MILab small animal SPECT system fitted with a multi-pinhole collimator with 0.4 mm resolution in 5-minute sections. They were subsequently sorted for different acquisition times and reconstructed using a vendor provided OS-EM algorithm with simultaneous 6 respiratory and 8 cardiac equal-time gates over each motion cycle. Using a group-wise B-spline non-rigid image-based registration method, the deformation fields of the respiratory motion (respiratory motion) were estimated and applied to each cardiac phase for respiratory motion correction. Then, the respiratory motion compensated cardiac gated SPECT images were similarly used to estimate cardiac motion (cardiac motion) and later transformed to a reference frame and summed. Finally, the reference frame was inverse-transformed using the estimated cardiac motion to each of the 8 cardiac frames. The cardiac gated images with dual R&C motion compensation were compared to those without correction but with post-smoothing filter. The results showed the dual R&C motion compensation significantly reduced image noise level. At the same time, the image resolution was improved by 10% to 40% depending on the different acquisition times when compared with that obtained without motion compensation at the same image noise level. We conclude that dual R&C motion compensation provides significant reduction of noise level in 4D cardiac gated small animal MP SPECT images with minimum degradation of resolution. The improved image quality can be traded for reduction of acquisition time or radiation dose to the animal.
AB - We investigated the performance of a post reconstruction dual respiratory and cardiac (R&C) motion compensation method for improved image quality of 4D cardiac gated small animal myocardial perfusion (MP) SPECT images. A normal mouse was injected with ∼8 mCi of Tc-99m sestamibi, anesthetized, fitted with ECG leads for cardiac gating signal acquisition, and placed on top of a pressure gauge bellow for respiratory motion measurements. A 2-hour list-mode dataset was acquired using a MILab small animal SPECT system fitted with a multi-pinhole collimator with 0.4 mm resolution in 5-minute sections. They were subsequently sorted for different acquisition times and reconstructed using a vendor provided OS-EM algorithm with simultaneous 6 respiratory and 8 cardiac equal-time gates over each motion cycle. Using a group-wise B-spline non-rigid image-based registration method, the deformation fields of the respiratory motion (respiratory motion) were estimated and applied to each cardiac phase for respiratory motion correction. Then, the respiratory motion compensated cardiac gated SPECT images were similarly used to estimate cardiac motion (cardiac motion) and later transformed to a reference frame and summed. Finally, the reference frame was inverse-transformed using the estimated cardiac motion to each of the 8 cardiac frames. The cardiac gated images with dual R&C motion compensation were compared to those without correction but with post-smoothing filter. The results showed the dual R&C motion compensation significantly reduced image noise level. At the same time, the image resolution was improved by 10% to 40% depending on the different acquisition times when compared with that obtained without motion compensation at the same image noise level. We conclude that dual R&C motion compensation provides significant reduction of noise level in 4D cardiac gated small animal MP SPECT images with minimum degradation of resolution. The improved image quality can be traded for reduction of acquisition time or radiation dose to the animal.
KW - SPECT
KW - compensation
KW - dual gating
KW - respiratory and cardiac motion
KW - small animal imaging
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U2 - 10.1109/NSSMIC.2015.7582214
DO - 10.1109/NSSMIC.2015.7582214
M3 - Conference contribution
AN - SCOPUS:84994311359
T3 - 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
BT - 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
Y2 - 31 October 2015 through 7 November 2015
ER -