Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience

Linda C. Chu; Seyoun Park; Satomi Kawamoto; Yan Wang; Yuyin Zhou; Wei Shen; Zhuotun Zhu; Yingda Xia; Lingxi Xie; Fengze Liu; Qihang Yu; Daniel F. Fouladi; Shahab Shayesteh; Eva Zinreich; Jefferson S. Graves; Karen M. Horton; Alan L. Yuille; Ralph H. Hruban; Kenneth W. Kinzler; Bert Vogelstein; Elliot K. Fishman

doi:10.1016/j.jacr.2019.05.034

Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience

Linda C. Chu, Seyoun Park, Satomi Kawamoto, Yan Wang, Yuyin Zhou, Wei Shen, Zhuotun Zhu, Yingda Xia, Lingxi Xie, Fengze Liu, Qihang Yu, Daniel F. Fouladi, Shahab Shayesteh, Eva Zinreich, Jefferson S. Graves, Karen M. Horton, Alan L. Yuille, Ralph H. Hruban, Kenneth W. Kinzler, Bert VogelsteinElliot K. Fishman

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Original language	English (US)
Pages (from-to)	1338-1342
Number of pages	5
Journal	Journal of the American College of Radiology
Volume	16
Issue number	9
DOIs	https://doi.org/10.1016/j.jacr.2019.05.034
State	Published - Sep 2019

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.jacr.2019.05.034

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Chu, L. C., Park, S., Kawamoto, S., Wang, Y., Zhou, Y., Shen, W., Zhu, Z., Xia, Y., Xie, L., Liu, F., Yu, Q., Fouladi, D. F., Shayesteh, S., Zinreich, E., Graves, J. S., Horton, K. M., Yuille, A. L., Hruban, R. H., Kinzler, K. W., ... Fishman, E. K. (2019). Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience. Journal of the American College of Radiology, 16(9), 1338-1342. https://doi.org/10.1016/j.jacr.2019.05.034

Chu, LC, Park, S, Kawamoto, S, Wang, Y, Zhou, Y, Shen, W, Zhu, Z, Xia, Y, Xie, L, Liu, F, Yu, Q, Fouladi, DF, Shayesteh, S, Zinreich, E, Graves, JS, Horton, KM, Yuille, AL, Hruban, RH , Kinzler, KW , Vogelstein, B & Fishman, EK 2019, 'Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience', Journal of the American College of Radiology, vol. 16, no. 9, pp. 1338-1342. https://doi.org/10.1016/j.jacr.2019.05.034

@article{8a4cb7f610364984bb6705bdb7a12c79,

title = "Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience",

author = "Chu, {Linda C.} and Seyoun Park and Satomi Kawamoto and Yan Wang and Yuyin Zhou and Wei Shen and Zhuotun Zhu and Yingda Xia and Lingxi Xie and Fengze Liu and Qihang Yu and Fouladi, {Daniel F.} and Shahab Shayesteh and Eva Zinreich and Graves, {Jefferson S.} and Horton, {Karen M.} and Yuille, {Alan L.} and Hruban, {Ralph H.} and Kinzler, {Kenneth W.} and Bert Vogelstein and Fishman, {Elliot K.}",

note = "Funding Information: The Felix Project, funded by the Lustgarten Foundation, is a multidisciplinary research collaboration developed to use deep learning to automatically find the pancreas and PDAC on CT scans. Our team comprises experts in medical imaging, pathology, cancer research, and computer science. We hold weekly research meetings to share our knowledge and findings, to troubleshoot, and to enhance the algorithm. Funding Information: Drs Chu, Park, Kawamoto, Fouladi, Shayesteh, Horton, Yuille, and Fishman and Mr Graves have received research support from the Lustgarten Foundation. Drs Chu, Park, and Fishman have received additional research support from the Emerson Collective. Dr Chu receives grant support from the Lustgarten Foundation and the Emerson Collective. Dr Kawamoto receives grant support from the Lustgarten Foundation. Mr Liu receives grant support from the Lustgarten Foundation. Dr Fouladi receives grant support from the Lustgarten Foundation. Dr Shayesteh receives grant support from the Lustgarten Foundation. Mr Graves receives grant support from the Lustgarten Foundation. Dr Horton receives grant support from the Lustgarten Foundation. Dr Yuille receives grant support from the Lustgarten Foundation. Dr Hruban receives grant support from the National Institutes of Health. Dr Kinzler is a founder of PapGene and Personal Genome Diagnostics and a member of the scientific advisory boards of Eisai-Morphotek, Syxmex-Inostics, Cage, and Neophore. These companies, as well as other companies, have licensed technologies from Johns Hopkins University, on which Dr Kinzler is an inventor. These licenses and relationships are associated with equity or royalty payments to Dr Kinzler. The terms of these arrangements are being managed by Johns Hopkins University in accordance with its conflict-of-interest policies. Dr Vogelstein is a founder of PapGene and Personal Genome Diagnostics and a member of the scientific advisory boards of Eisai-Morphotek, Sysmex-Inostics, Exelixis GP (Camden Partners), NeoPhore, and CAGE. The first four of these companies, as well as other companies, have licensed technologies from Johns Hopkins University, on which Dr Vogelstein is an inventor. These licenses and relationships are associated with equity or royalty payments to Dr Vogelstein. The terms of these arrangements are being managed by Johns Hopkins University in accordance with its conflict-of-interest policies. Dr Fishman has received grant support from Siemens, GE, and HipGraphics. All other authors state that they have no conflict of interest related to the material discussed in this article. The authors declare that they had full access to all of the data in this study, and the authors take complete responsibility for the integrity of the data and accuracy of the data analysis.",

year = "2019",

month = sep,

doi = "10.1016/j.jacr.2019.05.034",

language = "English (US)",

volume = "16",

pages = "1338--1342",

journal = "Journal of the American College of Radiology",

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TY - JOUR

T1 - Application of Deep Learning to Pancreatic Cancer Detection

T2 - Lessons Learned From Our Initial Experience

AU - Chu, Linda C.

AU - Park, Seyoun

AU - Kawamoto, Satomi

AU - Wang, Yan

AU - Zhou, Yuyin

AU - Shen, Wei

AU - Zhu, Zhuotun

AU - Xia, Yingda

AU - Xie, Lingxi

AU - Liu, Fengze

AU - Yu, Qihang

AU - Fouladi, Daniel F.

AU - Shayesteh, Shahab

AU - Zinreich, Eva

AU - Graves, Jefferson S.

AU - Horton, Karen M.

AU - Yuille, Alan L.

AU - Hruban, Ralph H.

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

AU - Fishman, Elliot K.

N1 - Funding Information: The Felix Project, funded by the Lustgarten Foundation, is a multidisciplinary research collaboration developed to use deep learning to automatically find the pancreas and PDAC on CT scans. Our team comprises experts in medical imaging, pathology, cancer research, and computer science. We hold weekly research meetings to share our knowledge and findings, to troubleshoot, and to enhance the algorithm. Funding Information: Drs Chu, Park, Kawamoto, Fouladi, Shayesteh, Horton, Yuille, and Fishman and Mr Graves have received research support from the Lustgarten Foundation. Drs Chu, Park, and Fishman have received additional research support from the Emerson Collective. Dr Chu receives grant support from the Lustgarten Foundation and the Emerson Collective. Dr Kawamoto receives grant support from the Lustgarten Foundation. Mr Liu receives grant support from the Lustgarten Foundation. Dr Fouladi receives grant support from the Lustgarten Foundation. Dr Shayesteh receives grant support from the Lustgarten Foundation. Mr Graves receives grant support from the Lustgarten Foundation. Dr Horton receives grant support from the Lustgarten Foundation. Dr Yuille receives grant support from the Lustgarten Foundation. Dr Hruban receives grant support from the National Institutes of Health. Dr Kinzler is a founder of PapGene and Personal Genome Diagnostics and a member of the scientific advisory boards of Eisai-Morphotek, Syxmex-Inostics, Cage, and Neophore. These companies, as well as other companies, have licensed technologies from Johns Hopkins University, on which Dr Kinzler is an inventor. These licenses and relationships are associated with equity or royalty payments to Dr Kinzler. The terms of these arrangements are being managed by Johns Hopkins University in accordance with its conflict-of-interest policies. Dr Vogelstein is a founder of PapGene and Personal Genome Diagnostics and a member of the scientific advisory boards of Eisai-Morphotek, Sysmex-Inostics, Exelixis GP (Camden Partners), NeoPhore, and CAGE. The first four of these companies, as well as other companies, have licensed technologies from Johns Hopkins University, on which Dr Vogelstein is an inventor. These licenses and relationships are associated with equity or royalty payments to Dr Vogelstein. The terms of these arrangements are being managed by Johns Hopkins University in accordance with its conflict-of-interest policies. Dr Fishman has received grant support from Siemens, GE, and HipGraphics. All other authors state that they have no conflict of interest related to the material discussed in this article. The authors declare that they had full access to all of the data in this study, and the authors take complete responsibility for the integrity of the data and accuracy of the data analysis.

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Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience

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