TY - JOUR
T1 - Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography
AU - Ong, Sally S.
AU - Hsu, S. Tammy
AU - Grewal, Dilraj
AU - Arevalo, J. Fernando
AU - El-Dairi, Mays A.
AU - Toth, Cynthia A.
AU - Vajzovic, Lejla
N1 - Funding Information:
This study was funded by the International Association of Government Officials (iGO) Fund, Knights Templar Eye Foundation, Research to Prevent Blindness Unrestricted Grant to Duke Eye Center, NIH RO1 EY25009, NIH P30 EY005722 (Duke Eye Center Core Grant), Research equipment (Spectralis tabletop and Flex module), and grant provided by Heidelberg Engineering.
Funding Information:
DG has received research grants from Alimera Sciences and Allergan. JFA holds a patent from Springer SBM LLC; is a consultant for Turing Pharmaceuticals LLC, DORC International B.V., Allergan Inc., Bayer, and Mallinckrodt; and has received research grants from TOPCON. MAE has received research grants from the Knights Templar Eye Foundation. CAT receives royalties from Alcon and has received a research grant from NIH (RO1 EY25009). LV receives research grants from Janssen Pharmaceutical, Roche, DORC, Second Sight, Alcon, Genentech, B&L, and Alimera Sciences. STH declares that she has no conflict of interest. SSO declares that she has no conflict of interest.
Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Purpose: Compared with fluorescein angiography (FA), the gold standard for diagnosing choroidal neovascularization (CNV) activity, optical coherence tomography angiography (OCTA) is non-invasive without risks associated with fluorescein dye use, and may be especially advantageous in the diagnosis and monitoring of children with CNV. Methods: Eight eyes from eight patients aged 12 months to 18 years were imaged with the investigational Spectralis OCTA (version 6.9, Heidelberg Engineering, Heidelberg, Germany) and the RTVue XR Avanti (Optovue Inc., Fremont, CA, USA). Two patients were imaged during examination under anesthesia while six patients were imaged in the clinic. Demographic information, ocular characteristics, treatment history, and imaging studies (color photos, fluorescein angiography, OCT) were collected and reviewed. Results: Three eyes had active CNV while five had quiescent CNV at the time of imaging. CNV was idiopathic or secondary to trauma, retinal vascular dysgenesis versus retinopathy of prematurity, pigmentary retinopathy, Best vitelliform macular dystrophy, panuveitis, morning glory disc anomaly, and optic disc drusen. OCTA of two active CNV demonstrated presence of a main trunk with multiple fine capillaries, vessel loops, and anastomoses. OCTA was repeated after treatment for two CNV and demonstrated a decrease in size with loss of fine capillaries, vessel loops, and anastomoses. For the third active CNV, OCTA verified flow in the CNV complex despite the uncertainty of FA hyperfluorescence in the setting of grossly abnormal retinal vasculature. The five quiescent CNV all lacked fine capillaries, vessel loops, and anastomoses on OCTA. Conclusion: OCTA demonstrates morphological differences between active and quiescent pediatric CNV.
AB - Purpose: Compared with fluorescein angiography (FA), the gold standard for diagnosing choroidal neovascularization (CNV) activity, optical coherence tomography angiography (OCTA) is non-invasive without risks associated with fluorescein dye use, and may be especially advantageous in the diagnosis and monitoring of children with CNV. Methods: Eight eyes from eight patients aged 12 months to 18 years were imaged with the investigational Spectralis OCTA (version 6.9, Heidelberg Engineering, Heidelberg, Germany) and the RTVue XR Avanti (Optovue Inc., Fremont, CA, USA). Two patients were imaged during examination under anesthesia while six patients were imaged in the clinic. Demographic information, ocular characteristics, treatment history, and imaging studies (color photos, fluorescein angiography, OCT) were collected and reviewed. Results: Three eyes had active CNV while five had quiescent CNV at the time of imaging. CNV was idiopathic or secondary to trauma, retinal vascular dysgenesis versus retinopathy of prematurity, pigmentary retinopathy, Best vitelliform macular dystrophy, panuveitis, morning glory disc anomaly, and optic disc drusen. OCTA of two active CNV demonstrated presence of a main trunk with multiple fine capillaries, vessel loops, and anastomoses. OCTA was repeated after treatment for two CNV and demonstrated a decrease in size with loss of fine capillaries, vessel loops, and anastomoses. For the third active CNV, OCTA verified flow in the CNV complex despite the uncertainty of FA hyperfluorescence in the setting of grossly abnormal retinal vasculature. The five quiescent CNV all lacked fine capillaries, vessel loops, and anastomoses on OCTA. Conclusion: OCTA demonstrates morphological differences between active and quiescent pediatric CNV.
KW - CNV in children
KW - OCTA
KW - Optical coherence tomography angiography
KW - Pediatric choroidal neovascularization
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U2 - 10.1007/s00417-019-04535-4
DO - 10.1007/s00417-019-04535-4
M3 - Article
C2 - 31758259
AN - SCOPUS:85075384103
SN - 0721-832X
VL - 258
SP - 89
EP - 98
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
IS - 1
ER -