Abstract
Apoptosis repressor with caspase recruitment domain is expressed at high levels in brain and myogenic tissues, consistent with a role to inhibit apoptosis in the terminally differentiated cells. Expression of ARC in cancers is not known. In this study, we reported that ARC was highly expressed in various non-myogenic and non-neurogenic human and rat cancer cell lines. Unexpectedly, ARC was localized almost exclusively to the nuclei of cancer cells, which was unlike the cytoplasmic localization of ARC in non-cancer cells. Furthermore, nuclear ARC in cancer cells did not co-localize with nucleolus protein of 30 kDa, an alternatively spliced ARC isoform. These findings indicate that ARC is distributed differently in cancer cells than non-cancer cells and thus might play a role in neoplastic transformation.
Original language | English (US) |
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Pages (from-to) | 2411-2415 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 579 |
Issue number | 11 |
DOIs | |
State | Published - Apr 25 2005 |
Externally published | Yes |
Keywords
- Apoptosis
- Apoptosis repressor with caspase recruitment domain
- Cancer cells
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology