TY - JOUR
T1 - Apoptosis in perinatal hypoxic-ischemic brain injury
T2 - How important is it and should it be inhibited?
AU - Northington, Frances J.
AU - Graham, Ernest M.
AU - Martin, Lee J.
N1 - Funding Information:
Portions of this work were originally presented as a lecture for the Brain Club at the Pediatric Academic Societies Meeting, May 2, 2004 in San Francisco, CA. Special thanks are due to Drs. Donna Ferriero, Estelle Gauda, Declan O'Riordan, Jeffrey Perlman, Edward Lawson and John Kattwinkel, Ms. Debbie Flock, Ms. Ann Sheldon, and Mr. Devin Mack. FJN is supported by NS45059. LJM is supported by AG16282, NS34100, and NS20020.
PY - 2005/12/15
Y1 - 2005/12/15
N2 - The discovery of safe and effective therapies for perinatal hypoxia-ischemia (HI) and stroke remains an unmet goal of perinatal medicine. Hypothermia and antioxidants such as allopurinol are currently under investigation as treatments for neonatal HI. Drugs targeting apoptotic mechanisms are currently being studied in adult diseases such as cancer, stroke, and trauma and have been proposed as potential therapies for perinatal HI and stroke. Before developing antiapoptosis therapies for perinatal brain injury, we must determine whether this form of cell death plays an important role in these injuries and if the inhibition of these pathways promotes more benefit than harm. This review summarizes current evidence for apoptotic mechanisms in perinatal brain injury and addresses issues pertinent to the development of antiapoptosis therapies for perinatal HI and stroke.
AB - The discovery of safe and effective therapies for perinatal hypoxia-ischemia (HI) and stroke remains an unmet goal of perinatal medicine. Hypothermia and antioxidants such as allopurinol are currently under investigation as treatments for neonatal HI. Drugs targeting apoptotic mechanisms are currently being studied in adult diseases such as cancer, stroke, and trauma and have been proposed as potential therapies for perinatal HI and stroke. Before developing antiapoptosis therapies for perinatal brain injury, we must determine whether this form of cell death plays an important role in these injuries and if the inhibition of these pathways promotes more benefit than harm. This review summarizes current evidence for apoptotic mechanisms in perinatal brain injury and addresses issues pertinent to the development of antiapoptosis therapies for perinatal HI and stroke.
KW - Cell death continuum
KW - Excitotoxicity
KW - Hypoxia-ischemia
KW - Perinatal brain injury
KW - Programmed cell death
KW - Stroke
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U2 - 10.1016/j.brainresrev.2005.07.003
DO - 10.1016/j.brainresrev.2005.07.003
M3 - Review article
C2 - 16216332
AN - SCOPUS:27844480078
SN - 0165-0173
VL - 50
SP - 244
EP - 257
JO - Brain Research Reviews
JF - Brain Research Reviews
IS - 2
ER -